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Synlett 2000; 2000(12): 1775-1776
DOI: 10.1055/s-2000-8673
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CAL-B Catalyzed Enantioselective Synthesis of Cyanohydrins - A Facile Route to Versatile Building Blocks

Ulf Hanefeld* , Yuxin Li, Roger A. Sheldon, Thomas Maschmeyer
  • *Applied Organic Chemistry and Catalysis, DelftChemTech, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands; Fax +31-15-278 4289; E-mail: hanefeld@tnw.tudelft.nl
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Publication Date:
31 December 2000 (online)

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A straightforward process for the preparation of optically active cyanohydrins, important building blocks for the synthesis of drugs and agrochemicals, has been established. Lipase B from Candida antarctica (CAL-B) catalyzes the kinetic resolution of racemic cyanohydrin acetates under mild conditions: optimization of the process led to a user-friendly synthesis of (S)- and (R)-cyanohydrins.

cyanohydrin - lipase - kinetic resolution - Candida antarctica - stereoselective synthesis

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