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Synlett 2001; 2001(5): 0712-0714
DOI: 10.1055/s-2001-13354
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An Intramolecular Sulfoxide Alkylation-Elimination Approach to the [1,2,3]Triazolo[1,5-a]pyrimidine Ring System

Karl R. Gibson* , Steven R. Thomas, Michael Rowley
  • *Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK; Fax + 44 1279 44 03 90; E-mail: karl gibson@merck.com
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Publication Date:
31 December 2001 (online)

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A novel approach to the [1,2,3]triazolo[1,5-a]pyrimidine ring system has been developed. The key reaction step involves an unusual one-pot intramolecular sulfoxide alkylation-elimination reaction.

sulfoxides - alkylations - cyclisations - eliminations - rearrangements