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Synthesis 2003(8): 1157-1159
DOI: 10.1055/s-2003-39395
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Effective Fluorination Reaction with Et3N˙3HF Under Microwave Irradiation

Tomotake Inagaki, Tsuyoshi Fukuhara, Shoji Hara*
Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Fax: +81(11)7066556; e-Mail: hara@org-mc.eng.hokudai.ac.jp;
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Publication History

Received 14 February 2003
Publication Date:
26 May 2003 (online)

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Abstract

Fluorination reaction of epoxides and alkyl mesylates can be effectively achieved by reaction with Et3N˙3HF under microwave irradiation. The reaction time could be greatly reduced compared to the reaction under thermal conditions. The reactions were completed in a few minutes and the use of large excess of reagents could be avoided.

Key words

microwave irradiation - epoxides - fluorination - ring opening - Et3N˙3HF

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