A Novel One-Pot Stereoselective Synthesis of N-[(E)-Homocinnamyl] Amides

Wanli Chen; Xian Huang; Hongwei Zhou

doi:10.1055/s-2004-822369

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Synthesis 2004(10): 1573-1576
DOI: 10.1055/s-2004-822369

PAPER

A Novel One-Pot Stereoselective Synthesis of N-[(E)-Homocinnamyl] Amides

Wanli Chen^a, Xian Huang*^a,b, Hongwei Zhou^a
^a Department of Chemistry, Zhejiang University (Campus Xixi), Hangzhou 310028, P. R. China
^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
Fax: +86(571)88807077; e-Mail: huangx@mail.hz.zj.cn;

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Publication History

Received 23 February 2004
Publication Date:
18 May 2004 (online)

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Abstract

N-[(E)-Homocinnamyl] amides were stereoselectively synthesized by the reaction of the methylenecyclopropanes (MCPs) with nitriles under acidic conditions in moderate yields in a one-pot manner.

Key words

Ritter reaction - methylenecyclopropanes - nitriles - stereoselectively - N-homocinnamyl amides

Reference

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