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Synthesis 2004(17): 2799-2804
DOI: 10.1055/s-2004-831249
DOI: 10.1055/s-2004-831249
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Novel 2-Aryl AICAR Derivatives
Further Information
Received
7 June 2004
Publication Date:
29 September 2004 (online)
Publication History
Publication Date:
29 September 2004 (online)
Abstract
Novel 2-aryl AICAR (5-Amino-1-β-d-ribofuranosylimidazole-4-carboxamide) derivatives 8 were synthesized via the Suzuki-Miyaura cross-coupling reactions of 8-bromoadenosine. Following conversion of the adenine moiety of 4 to hypoxanthine (5) and the introduction of a MEM group, hydrolysis of 7 gave desired 2-aryl AICAR derivatives 8.
Key words
nucleosides - cross-coupling - palladium - inosine - adenosine
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