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Synfacts 2006(1): 0001-0001  
DOI: 10.1055/s-2005-921655
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Copper-Mediated Synthesis of Azaphilones

Contributor(s): Philip Kocienski, John Cooksey
J. A. Porco*, J. Zhu, N. P. Grigoriadis, J. P. Lee
Boston University, USA
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

The azaphilones do not appear to have significant biological activity. The pyronoquinone chromophore is a key feature of some plant pigments. The biomimetic synthesis of S-15183a outlined above is only the second asymmetric synthesis of the quaternary center in the azaphilones, the previous synthesis being accomplished by Sorensen and co-workers (L. M. Stark, K. Pekari, E. J. Sorensen Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 12064-12066).