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Synfacts 2006(12): 1200-1200  
DOI: 10.1055/s-2006-955597
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Merrilactone A

Contributor(s): Philip Kocienski, Thomas Snaddon
M. Inoue*, T. Sato, M. Hirama
Tohoku University and Japan Science and Technology Agency, Sendai, Japan
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

Merrilactone A possesses neuroprotective and neuritogenic activity. The key feature in the synthesis is the use of a bulky 2,6-bis(trifluoromethyl)benzyl protecting group to induce selectivity in the deprotonation of the pseudo-meso-diketone E.