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Planta Med 1998; 64(6): 500-503
DOI: 10.1055/s-2006-957501
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

In vitro Antigenotoxic Activity of Novel Ginseng Saponin Metabolites Formed by Intestinal Bacteria

Byung-Hoon Lee1 , Sang-Jun Lee1 , 2 , Jang-Hyun Hui2 , Sooyong Lee3 , Jong-Hwan Sung4 , Jae-Doo Huh4 , Chang-Ku Moon5
  • 1College of Pharmacy, Wonkwang University, Iksan, Chonbuk, Korea
  • 2Department of Agricultural Chemistry, Kangwon National University, Chunchon, Kangwon-do, Korea
  • 3Institute of Environment and Life Sciences, Hallym University, Chunchon, Kangwon-do, Korea
  • 4Central Research Institute, IL HWA Co. Ltd., Guri, Kyonggi-do, Korea
  • 5College of Pharmacy, Seoul National University, Seoul, Korea
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Publication History

1997

1998

Publication Date:
01 February 2007 (online)

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Abstract

Ginseng saponin metabolites produced by human intestinal bacteria were evaluated for antigenotoxic properties by testing their effects on benzo[a]pyrene (B[a]P)-induced mutagenicity and clastogenicity. They include 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), 20-O-[α-D-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (IH-902) and 20-O-[α-D-arabinofuranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (IH-903). IH-901, IH-902 and IH-903 inhibited the mutagenicity of B[a]P in a dose-dependent manner. In the chromosome aberration assay, IH-901 and IH-903 reduced the frequency of chromosome aberration induced by B[a]P. These results suggest that the ginseng saponin metabolites tested in the present study have potential as chemopreventive agents.

Key words

Panax ginseng - Araliaceae - ginseng saponin metabolites - antimutagenicity - anticlastogenicity - benzo[a]pyrene - chemoprevention

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