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Planta Med 1995; 61(1): 58-61
DOI: 10.1055/s-2006-958000
Paper

© Georg Thieme Verlag Stuttgart · New York

Novel Furostanol Glycosides from Allium macrostemon

Junpeng Peng1 , 2 , Xinsheng Yao1 , Hisayoshi Kobayashi3 , Chengyu Ma2
  • 1Department of Phytochemistry, Shenyang College of Pharmacy, 103 Wen-hua Road, Shenyang, 110015, People's Republic of China
  • 2Department of Applied Medicine Research, Institute of Radiation Medicine, Academy of Military Medical Sciences, 27 Tai-ping Road, Beijing, 100850, People's Republic of China
  • 3Institute of Applied Microbiology, Tokyo University, Tokyo, 113, Japan
Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Further studies by means of preparative HPLC led to the isolation of two new furostanol saponins, macrostemonosides G (1) and I (3), along with an artifact, macrostemonoside H (2) from the bulbs of Allium macrostemon Bunge. On the basis of chemical evidence and spectral analyses (1H-, 13C-NMR, 1H-1H COSY, 1H-13C COSY, HMBC, and FAB-MS), the structure of 1 was established as 26-O-β-D-glucopyranosyl-22-hydroxy-5β-furost-25(27)-ene-3β12β,26-triol 3-O-β-D-glucopyranosyl(1→2)-β-D-galactopyranoside and 2 as the 22-methoxy derivative of 1; 3 was deduced to be 26-O-β-D-glucopyranosyl-22-hydroxy-5β-furost-25(27)-ene-12-one-3β,26-diol 3-O-β-D-glucopyranosyl(1→2)-β-D-galactopyranoside. Preliminary pharmacological tests showed that macrostemonoside G (1) could inhibit ADP-induced human platelet aggregation in vitro (IC50 = 0.871 mM).

Key words

Allium macrostemon Bunge - Liliaceae - furostanol saponin - macrostemonoside G - macrostemonoside H - macrostemonoside I - inhibition of ADP-induced human platelet aggregation

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