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DOI: 10.1055/s-2006-960914
© Georg Thieme Verlag Stuttgart · New York
Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta Extracts on the Central Nervous System
Publication History
1989
Publication Date:
05 January 2007 (online)
Abstract
We report the effects of aqueous extracts of the microalgae Dunaliella tertiolecta Butcher (Chlorophyceae) and Phaeodactylum tricornutum Bohlin (Bacillariophyceae) on oxotremorin-induced cholinergic symptoms, amphetamine-induced hypermotility, pentylenetetrazole-induced convulsions, and Rota-rod test performance. Both extracts significantly reduced rectal temperature, spontaneous motor activity, and time on the Rota-rod and increased the number of mice falling off the rod before 180 s, but neither protected against pentylenetetrazole-induced convulsions or against oxotremorin-induced tremor, salivation, and diarrhoea.
Key words
Phaeodactylum tricornutum - Dunaliella tertiolecta - oxotremorin - amphetamine - pentylenetetrazole