Pd-Mediated Fluorination of Arylboronic Acids

Significance

A novel Pd-mediated fluorination reaction using selectfluor and arylboronic acids has been disclosed. The reaction tolerates a large variety of functional groups including sensitive functionalities such as aldehydes and bromo substituents, as well as protic functionalities. The fluorination reaction also proceeds with electron-rich arylboronic acids. It was shown that the pyridyl sulfonamide ligand remained coordinated to the Pd center throughout the reaction, which may be a useful starting point for the development of a catalytic protocol.