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Synthesis 2012; 44(23): 3678-3682
DOI: 10.1055/s-0032-1317341
DOI: 10.1055/s-0032-1317341
paper
A Mild and Efficient Synthesis of 2-Oxazolines via Transamidation–Cyclodehydrosulfurisation of Thioamides with 2-Aminoethanol
Further Information
Publication History
Received: 17 July 2012
Accepted after revision: 10 September 2012
Publication Date:
02 October 2012 (online)
Abstract
Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(β-hydroxyethyl)thioamides, has been utilised for the mild and efficient synthesis of 2-oxazolines. The developed protocol was found to be of general applicability.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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