Copper-Mediated Synthesis of Monofluoro Aryl Acetates via Decarboxylative Cross-Coupling
Received: 27 May 2017
Accepted after revision: 03 July 2017
08 August 2017 (eFirst)
Dedicated to Victor Snieckus on the occasion of his 80th birthday.
We report the Cu-promoted oxidative cross-coupling of α-fluoromalonate half-esters and aryl boron reagents to deliver monofluoro α-aryl acetates under mild conditions (in air at room temperature). The reaction uses a simple, readily available monofluorinated building block to generate arylated compounds with functional groups that are not easily tolerated by existing methods, such as aryl bromides, iodides, pyridines, and pyrimidines.