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Synthesis 2017; 49(18): 4292-4298
DOI: 10.1055/s-0036-1588876
DOI: 10.1055/s-0036-1588876
special topic
Facile Construction of Pyrrolo[1,2-a]indolenine Scaffold via Diastereoselective [3+2] Annulation of Donor–Acceptor Cyclopropane with Indolenine
We gratefully acknowledge the financial support from the National Natural Science Foundation of China (No. 21576296) and Central South University.
Further Information
Publication History
Received: 11 April 2017
Accepted after revision: 15 May 2017
Publication Date:
19 July 2017 (online)
Published as part of the Special Topic Modern Cyclization Strategies in Synthesis
Abstract
A novel synthetic protocol for the assembly of pyrrolo[1,2-a]indolenine has been developed through a highly diastereoselective [3+2] annulation of 1,1-cyclopropanediesters with indolenines in the presence of catalytic Yb(OTf)3. This new strategy allows a facile construction of the multicyclic system with the flexible variation on the substituents in high yields (up to 86%) with excellent diastereoselectivities (>20:1 dr) in most cases.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588876.
- Supporting Information
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