Synthesis 2017; 49(21): 4719-4730
DOI: 10.1055/s-0036-1590913
review
© Georg Thieme Verlag Stuttgart · New York

Recent Advances in Transition-Metal-Free Aryl C–B Bond Formation

Kai Chena, Linghua Wangb, Ge Meng*a, Pengfei Li*b
  • aSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, P. R. of China   Email: mengge@mail.xjtu.edu.cn
  • bFrontier Institute of Science and Technology and Frontier Institute of Chemistry, Xi’an Jiaotong University, Xi’an 710054, P. R. of China   Email: lipengfei@mail.xjtu.edu.cn
Financial support was provided by the NSFC (Nos. 21672168 and 21472146), the Ministry of Science and Technology of PRC (No. 2014CB548200) and the China Postdoctoral Science Foundation (No. 2017M613103).
Further Information

Publication History

Received: 23 May 2017

Accepted after revision: 19 June 2017

Publication Date:
26 September 2017 (eFirst)

Published as part of the Special Topic Modern Strategies for Borylation in Synthesis

Abstract

Arylboronic acids and their derivatives are widely used in organic synthesis. Conventional methods for their preparation require either reactive organometallic reagents or transition-metal-mediated processes. In recent years, transition-metal-free reactions for aryl C–B bond formation that obviate preformed organometallic reagents have gained interest and have developed rapidly. These new reactions have shown significant advantages for the preparation of functionalized molecules. In this review, an overview of the recent advances in transition-metal-free aromatic borylation reactions is provided.

1 Introduction

2 Transition-Metal-Free Transformations of CAr–N Bonds to CAr–B Bonds

3 Transition-Metal-Free Transformations of CAr–X Bonds to CAr–B Bonds

4 Transition-Metal-Free Transformations of CAr–H Bonds to CAr–B Bonds

5 Conclusion