Transition-Metal-Catalyzed Alkenyl sp2 C–H Activation: A Short Account

Manikantha Maraswami; Teck-Peng Loh

doi:10.1055/s-0037-1611649

Synthesis, Inhaltsverzeichnis

CC BY ND NC 4.0 · Synthesis 2019; 51(05): 1049-1062
DOI: 10.1055/s-0037-1611649

short review

Copyright with the author

Transition-Metal-Catalyzed Alkenyl sp² C–H Activation: A Short Account

Manikantha Maraswami

^aDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616, Singapore eMail: teckpeng@ntu.edu.sg

,

Teck-Peng Loh *

^aDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616, Singapore eMail: teckpeng@ntu.edu.sg

^bInstitute of Advanced Synthesis, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, Jiangsu 210009, P. R. of China

^cHefei National Laboratory for Physical Sciences at the Microscale, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), University of Science and Technology of China, Hefei, Anhui 230026, P. R. of China

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Abstract

Alle Artikel dieser Rubrik

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

Alkenes are ubiquitous in Nature and their functionalization continues to attract attention from the scientific community. On the other hand, activation of alkenyl sp² C–H bonds is challenging due to their chemical properties. In this short account, we elucidate, discuss and describe the utilization of transition-metal catalysts in alkene activation and provide useful strategies to synthesize organic building blocks in an efficient and sustainable manner.

1 Introduction

2 Breakthrough

3 Controlling E/Z, Z/E Selectivity

3.1 Esters and Amides as Directing Groups

3.2 The Chelation versus Non-Chelation Concept

4 Other Alkene Derivatives

5 Intramolecular C–H Activation

6 Conclusion and Future Projects

Key words

transition metals - enamides - acrylamides - macrocycles - acrylates - alkenylation - alkynylation

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Referenzen

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