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Synthesis 2020; 52(08): 1223-1230
DOI: 10.1055/s-0039-1690737
DOI: 10.1055/s-0039-1690737
special topic
Synthesis of Phenanthrenes via Palladium-Catalyzed Three-Component Domino Reaction of Aryl Iodides, Internal Alkynes, and o-Bromobenzoic Acids
This work was supported by the National Natural Science Foundation of China (21572051, 21602057, 21901071, and 21971061), Scientific Research Foundation of Hunan Provincial Education Department (18A002), and Science and Technology Planning Project of Hunan Province (2018TP1017).Further Information
Publication History
Received: 28 August 2019
Accepted after revision: 16 October 2019
Publication Date:
29 October 2019 (online)
Published as part of the Special Topic Domino C–H Functionalization Reaction/Cascade Catalysis
Abstract
A new palladium-catalyzed domino alkyne insertion/C–H activation/decarboxylation sequence has been developed, which provides an efficient approach for synthesizing a variety of functionalized phenanthrenes in moderate to good yields. The method shows broad substrate scope and good functional group tolerance by employing readily available materials, including aryl iodides, internal alkynes, and o-bromobenzoic acids, as three-component coupling partners.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690737.
- Supporting Information
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