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Synthesis 2021; 53(01): 51-64
DOI: 10.1055/s-0040-1707234
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Advances in Copper-Catalyzed Radical C–H Bond Activation Using N–F Reagents

José María Muñoz-Molina∗
,
Tomás R. Belderrain∗
,
Pedro J. Pérez  ∗
Laboratorio de Catálisis Homogénea, Unidad Asociada al CSIC, CIQSO-Centro de Investigación en Química Sostenible and Departamento de Química, Universidad de Huelva, Campus de El Carmen s/n, 21007-Huelva, Spain   Email: perez@ciqso.uhu.es
› Author AffiliationsWe thank Ministerio de Economía y Competitividad (MINECO) (No. CTQ2017-82893-C2-1-R) and Universidad de Huelva (No. PO FEDER 2014-2020 UHU-1254043) for grants.
Further Information

Publication History

Received: 10 June 2020

Accepted after revision: 07 July 2020

Publication Date:
25 August 2020 (online)

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Abstract

This Short Review is aimed at giving an update in the area of copper-catalyzed C–H functionalization involving nitrogen-centered radicals generated from substrates containing N–F bonds. These processes include intermolecular Csp3–H bond functionalization, remote Csp3–H bond functionalization via intramolecular hydrogen atom transfer (HAT), and Csp2–H bond functionalization, which might be of potential use in industrial applications in the future.

1 Introduction

2 Intermolecular Csp3–H Functionalization

3 Remote Csp3–H Functionalization

4 Csp2–H Functionalization

5 Conclusion

Key words

copper catalysis - C–H bond functionalization - amination - nitrogen–fluorine bond - radical fluorination
 

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