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DOI: 10.1055/s-0042-1751580
Stereoselective Synthesis of Unsymmetrical 1,1-Diborylalkenes
Financial support was provided by the Research Grants Council of HKSAR (24307423) and the Chinese University of Hong Kong (4933621, 4053561).
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Dedicated to Professor Zuowei Xie on the occasion of his 60th birthday
Abstract
1,1-Diborylalkene, a class of important diboryl species, serves as the synthetic precursor of multisubstituted olefin, which is a prevalent building block in natural products, functional materials, and pharmaceuticals. Current methods mainly afford symmetrical 1,1-diborylalkenes, and late-stage differentiation of the two identical boryl groups is required to achieve selective difunctionalization. In comparison, stereoselective synthesis of unsymmetrical 1,1-diborylalkenes (UDBA) are less-explored. This Synpacts article provides a brief summary of the achievements in the synthesis of UDBAs. In particularly, we highlight our recent work on the unsymmetrical 1,1-diborylation of alkynes using a neutral sp2–sp3 diboron reagent to access UDBAs and their controllable stepwise derivatization.
1 Introduction
2 Background: Unsymmetrical 1,1-Diborylalkene Synthesis
3 Stereoselective Unsymmetrical 1,1-Diborylation of Alkynes with a Neutral sp2–sp3 Diboron Reagent
4 Summary and Outlook
Key words
boron - unsymmetrical 1,1-diborylalkene - diborylation - diboron reagent - stereoselectivePublication History
Received: 28 December 2023
Accepted after revision: 18 March 2024
Article published online:
02 April 2024
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