Recent Advances in the Transition-Metal-Free Arylation of Hetero­arenes

Sefa Uçar; Arif Daştan

doi:10.1055/a-1543-3743

Synthesis, Table of Contents

Synthesis 2021; 53(23): 4353-4374
DOI: 10.1055/a-1543-3743

short review

Recent Advances in the Transition-Metal-Free Arylation of Heteroarenes

Sefa Uçar∗

,

Arif Daştan ∗

Abstract

All articles of this category

Abstract

Transition-metal-free arylation reactions have attracted considerable attention for economic and environmental reasons over the past 40 years. In recent years, much effort has been made to develop efficient transition-metal-free approaches for the arylation of heteroarenes. Covering the literature from 2015 to early 2021, this review aims to provide a thorough overview of the synthetic and mechanistic aspects of these atom-economical and environmentally benign reactions.

1 Introduction

2 Arylation of Pre-functionalized Heteroarenes

2.1 Arylation of Heteroaryl Halides

2.2 Decarboxylative Arylation of Heteroarenes

3 Direct C–H Arylation of Heteroarenes

3.1 C(sp²)–H Arylation

3.2 C(sp³)–H Arylation

4 N-Arylation of Heteroarenes

5 Summary and Outlook

Key words

transition-metal-free reactions - arylation - heteroarenes - C–H functionalization

Full Text

References

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Recent Advances in the Transition-Metal-Free Arylation of Hetero­arenes

Recent Advances in the Transition-Metal-Free Arylation of Heteroarenes