The Povarov Reaction: A Versatile Method to Synthesize Tetrahydroquinolines, Quinolines and Julolidines

Abstract

The multicomponent Povarov reaction represents a powerful approach for the construction of substances containing N-heterocyclic frameworks. By using the Povarov reaction, in addition to accessing tetrahydroquinolines, quinolines and julolidines in a single step, it is possible to form the following new bonds: two Csp ³–Csp ³ and one Csp ³–Nsp ³, two Csp ²–Csp ² and one Csp ²–Nsp ², and four Csp ³–Csp ³ and two Csp ³–Nsp ¹, respectively. This short review discusses the main features of the Povarov reaction, including its mechanism, the reaction scope by employing different catalysts and substrates, as well as stereoselective versions.

1 Introduction

2 Mechanism of the Povarov Reaction

3 Tetrahydroquinolines

4 Quinolines

5 Julolidines

6 Concluding Remarks

Key-words

multicomponent reactions - N-heterocyclic compounds - reaction mechanism - catalysis

Publication History

Received: 31 December 2021

Accepted after revision: 10 March 2022

Accepted Manuscript online:
10 March 2022

Article published online:
17 May 2022

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