Recent Advances in the Trifluoromethylation Reactions of Isonitriles To Construct CF₃-Substituted N-Heterocycles

Abstract

Due to the increasing need for fluorine-containing drugs, the synthesis of organofluorine scaffolds has become a highly researched area of synthetic organic chemistry. The introduction of the trifluoromethyl group into the structure of an organic molecule has considerable potential and several advantages concerning the characteristics of the fluorinated pharmaceuticals. The incorporation of a CF₃ group at multiple bonds containing a nitrogen heteroatom is a relatively new field and currently it is an expanding area of synthetic chemistry. This short review summarizes, for the first time, recent developments in trifluoromethylation reactions of isonitriles.

1 Introduction

2 Trifluoromethylation Reactions of Isonitriles

2.1 Synthesis of Trifluoromethylated Phenanthridine Derivatives

2.2 Synthesis of Trifluoromethylated Quinoline Derivatives

2.3 Synthesis of Trifluoromethylated Isoquinoline Derivatives

2.4 Synthesis of Trifluoromethylated Indole Derivatives

2.5 Synthesis of Trifluoromethylated Pyridine Derivatives

3 Summary and Outlook

Key words

fluorine - functionalization - isonitriles - selectivity - trifluoromethylation - isocyanides

Publication History

Received: 23 December 2022

Accepted after revision: 26 January 2023

Accepted Manuscript online:
26 January 2023

Article published online:
06 March 2023

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