Abstract
Sulfonyl fluorides and sulfamoyl fluorides, as the most significant species among
sulfur(VI) fluorides, have garnered considerable attention in various fields, including
organic synthesis, materials science, chemical biology, and drug discovery. Fluorosulfonyl-containing
radical reagents have unique reactivity and exhibit notable advantages in constructing
complex organic molecules, achieving selective functional group transformations. This
short review provides a detailed introduction to the diverse applications of fluorosulfonyl-containing
radical reagents in organic synthesis, such as C–H bond functionalizations, difunctionalization
of olefins, and tandem reactions, highlighting their crucial roles in synthesizing
complex organic molecules
1 Introduction
2 Sulfuryl Chlorofluoride (FSO2Cl) as a Radical Reagent for the Synthesis of Sulfonyl Fluorides
3 FABI/IMSF as Solid-State Radical Reagents for the Synthesis of Sulfonyl Fluorides
4 Difunctionalization Reagents for the Synthesis of Bifunctional Sulfonyl Fluorides
5 Fluorosulfonamidation Reagents for the Synthesis of Sulfamoyl Fluorides
6 Conclusion
Key words
fluorosulfonyl-containing radical reagents - radical reactions - SuFEx click chemistry
- fluorine chemistry - sulfonyl fluorides - sulfamoyl fluorides
