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Synthesis 2025; 57(10): 1707-1720
DOI: 10.1055/a-2446-8046
DOI: 10.1055/a-2446-8046
short review
SuFEx Chemistry
Enhanced Synthesis of Sulfonyl Fluorides and Sulfamoyl Fluorides Using Fluorosulfonyl-Containing Radical Reagents
We are grateful for the financial support from the Basic and Applied Basic Research Foundation of Guangdong Province (2024A1515010680), the Natural Science Foundation of Guangxi Zhuang Autonomous Region (2021GXNSFDA075016), the Science and Technology Planning Project of Guangzhou (202102080070), the Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (2019B030301005) and open project funding of the Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, Hubei University.
Abstract
Sulfonyl fluorides and sulfamoyl fluorides, as the most significant species among sulfur(VI) fluorides, have garnered considerable attention in various fields, including organic synthesis, materials science, chemical biology, and drug discovery. Fluorosulfonyl-containing radical reagents have unique reactivity and exhibit notable advantages in constructing complex organic molecules, achieving selective functional group transformations. This short review provides a detailed introduction to the diverse applications of fluorosulfonyl-containing radical reagents in organic synthesis, such as C–H bond functionalizations, difunctionalization of olefins, and tandem reactions, highlighting their crucial roles in synthesizing complex organic molecules
1 Introduction
2 Sulfuryl Chlorofluoride (FSO2Cl) as a Radical Reagent for the Synthesis of Sulfonyl Fluorides
3 FABI/IMSF as Solid-State Radical Reagents for the Synthesis of Sulfonyl Fluorides
4 Difunctionalization Reagents for the Synthesis of Bifunctional Sulfonyl Fluorides
5 Fluorosulfonamidation Reagents for the Synthesis of Sulfamoyl Fluorides
6 Conclusion
Key words
fluorosulfonyl-containing radical reagents - radical reactions - SuFEx click chemistry - fluorine chemistry - sulfonyl fluorides - sulfamoyl fluoridesPublication History
Received: 31 July 2024
Accepted after revision: 21 October 2024
Accepted Manuscript online:
21 October 2024
Article published online:
02 December 2024
© 2024. Thieme. All rights reserved
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