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DOI: 10.1055/a-2535-1306
DOI: 10.1055/a-2535-1306
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Small Molecules in Medicinal Chemistry
Bioactive Molecules via Morita–Baylis–Hillman Chemistry
Abstract
Morita–Baylis–Hillman (MBH) chemistry was applied to the synthesis of a variety of new chemical entities and their bioactivity was evaluated. Various substances synthesized via MBH chemistry have: antimalarial, anti-inflammatory, antidiabetic, antimicrobial, antitubercular, and anticancer activity and also act as phosphodiesterase inhibitors. There are a few instances animal model and biology studies explored. Several hits and lead molecules are identified and their IC50 values listed. The simplicity of Morita–Baylis–Hillman chemistry provides a realistic, impactful option for the pharma industry.
1 Introduction
2 Antimalarial Activity
3 Anti-inflammatory Activity of MBH Adducts Coupled to Heterocycles
4 Antidiabetic Activity of Epalrestat Analogues Derived from MBH Adducts
5 Antimicrobial Activity
6 Antitubercular Activity of N-Cinnamyl-isatins
7 Inhibitors of Phosphodiesterase-3 (PDE3); Cardiotonic Agents
8 Anticancer Activity
9 Asymmetric Morita–Baylis–Hillman Reactions
10 Conclusion
Publication History
Received: 11 December 2024
Accepted after revision: 07 February 2025
Accepted Manuscript online:
07 February 2025
Article published online:
07 April 2025
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