A Massé Shot: Transition-Metal-Catalyzed Selective meta-C–H Functionalization (ortho-Metallation and para-Bromination Relay)

Abstract

Reviewed herein are a number of modern approaches for the meta-selective direct C–H functionalization of substituted arenes, including a recent discovery on Ru-catalyzed meta-bromination is also discussed with the mechanistically interesting features (ortho-metallation and para-functionalization relay).

1 Introduction

2 Transition-Metal-Mediated meta-C–H Activation

3 Ruthenium-Catalyzed meta-C–H Bromination

4 Conclusion and Future Directions

Key words

transition metal - Massé shot - bromination - ruthenium - meta-selective

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