Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals

Abstract

A highly enantioselective catalytic alkynylation of tetrahydroisoquinoline-based N-acyl hemiaminals has been developed. The method is simple and exhibits a broad scope with respect to both heterocycles and terminal alkynes, thus allowing for facile construction of a variety of enantiopure α-substituted tetrahydroisoquinolines.

Key words

asymmetric catalysis - alkynylation - N-acyl hemiaminals - tetrahydroisoquinolines - dihydroisoquinolines

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