Total Synthesis of Lycopalhine A

Dedicated to Professor Dieter Enders on the occasion of his 70^th birthday

Abstract

The total synthesis of lycopalhine A featuring the construction of a tricyclic system via cleavage of a cyclopropane ring and an ensuing intramolecular Michael addition, stereoselective introduction of a 2-aminoethyl moiety via a reaction of allyltrimethylsilane with a sulfonyliminium ion, and a stereoselective intramolecular aldol reaction is reported.

Key words

alkaloid - aminal - cyclopropanation - Michael addition - polycyclic system

• References

• 1 Visiting researcher from Otsuka Pharmaceutical Co., Ltd.

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