Synthesis, Table of Contents Synthesis 2019; 51(02): 573-577DOI: 10.1055/s-0037-1610291 paper © Georg Thieme Verlag Stuttgart · New YorkSynthesis and Antitumor Activity of Novel 1-Substituted 3-(4,5-Substituted 1,2,4-Triazol-3-yl)-β-carboline Derivatives George Brand a Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá - PR, 87020-900, Brazil Email: mhsarragiotto@uem.br , Carla M. B. Gomes a Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá - PR, 87020-900, Brazil Email: mhsarragiotto@uem.br , Willian F. Costa a Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá - PR, 87020-900, Brazil Email: mhsarragiotto@uem.br , Mary A. Foglio b Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas - SP, 13083-859, Brazil , Ana L. T. G. Ruiz c Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas, Campinas - SP, 13083-970, Brazil , Maria H. Sarragiotto* a Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá - PR, 87020-900, Brazil Email: mhsarragiotto@uem.br› Author AffiliationsRecommend Article Abstract Buy Article All articles of this category Abstract Schiff bases, 1,2,4-triazolo[4,3-d][1,2,3,4]thiatriazoles, and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles carrying the β-carboline nucleus were synthesized from 3-(4-amino-5-mercapto-1,2,4-triazol-3-yl)-β-carbolines. The compounds were evaluated for their in vitro antitumor activity against eight human cancer cell lines. The 1,2,4-triazolo[4,3-d][1,2,3,4]thiatriazole derivatives showed a broad spectrum of antitumor activity, with GI50 values lower than 13 μM for all cell lines tested. 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