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Synthesis 2019; 51(03): 643-663
DOI: 10.1055/s-0037-1610852
DOI: 10.1055/s-0037-1610852
short review
Recent Developments in Palladium-Catalysed Non-Directed C–H Bond Activation in Arenes
This work was supported by an EU COST ACTION CA15106 (CHAOS) STSM grant and a UiS Research Mobility grant.Further Information
Publication History
Received: 17 September 2018
Accepted after revision: 17 October 2018
Publication Date:
08 January 2019 (online)
Abstract
Over the past decades, organic chemists have focussed on developing new approaches to directed C–H functionalisations, where the site selectivity is steered by the presence of a directing group (DG). Nonetheless, in recent years, more and more non-directed strategies are being developed to circumvent the requisite directing group, making C–H functionalisations more generic. This short review focuses on the latest developments in palladium-catalysed non-directed C–H functionalisations of aromatic compounds.
1 Introduction
2 C–C Bond Formation
2.1 C–H Arylation
2.2 C–H Alkylation
2.3 C–H Alkenylation
2.4 C–H Carbonylation
3 C–Heteroatom Bond Formation
3.1 C–O Bond Formation
3.2 C–N Bond Formation
3.3 C–S Bond Formation
4 Conclusion
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