N-Halo Reagents: Modern Synthetic Approaches for Heterocyclic Synthesis

Abstract

Heterocyclic chemistry is an essential frontier in science and a source of novel biologically active compounds. The development of innovative synthetic methodologies that allows access to different heterocyclic rings is of critical interest to the scientific community. This review will focus on recent applications of N-halo compounds (e.g., N-halosuccinimides, trihaloisocyanuric acids, N-halosulfonamides, etc.) in heterocyclic construction via electrophilic cyclization, asymmetric halocyclization, oxidative cyclization, and radical processes.

1 Introduction

2 N-Halo Reagent Mediated Heterocyclic Construction and Functionalization

2.1 Electrophilic Halocyclizations

2.1.1 Asymmetric Halocyclizations

2.2 Radical Halocyclizations

2.3 Oxidative Halocyclizations

2.4 Miscellaneous Halocyclization Reactions

3 Summary and Outlook

Key words

heterocycles - N-halo compounds - electrophilic cyclization - N-haloimides - asymmetric halocyclization - condensation - oxidative cyclization­

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