Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy

Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermolecular cyclization manner. Various functional groups were well tolerated, and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of this method was demonstrated by modification of natural product derivatives and synthesis of bioactive molecules.

Key words

Catellani reaction - alkyl carbagermatranes - seven-membered carbocycles - cyclization - organogermanium

Publication History

Received: 03 February 2021

Accepted after revision: 14 April 2021

Article published online:
18 May 2021

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