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Synthesis 2023; 55(22): 3725-3736
DOI: 10.1055/a-2085-5934
DOI: 10.1055/a-2085-5934
short review
Synthetic Studies toward the Myrioneuron Alkaloids
This work was financially supported by UT Southwestern through the W. W. Caruth Jr. Scholarship, the Welch Foundation (I-2045), and the National Institutes of Health (T32GM127216 to J.M.A.). We also acknowledge funding via an UT Southwestern–American Cancer Society Institutional Research Grant (IRG-21-142-16) and Cancer Center Support Grant (P30CA142543).
Abstract
The Myrioneuron alkaloids are a relatively small family of plant-derived alkaloids that present an intriguing array of structural intricacy and biological properties. As such, these natural products have drawn interest from the synthetic community, resulting in creative total syntheses of several family members. This review showcases recent synthetic efforts towards these polycyclic alkaloids.
1 Introduction
1.1 Biological Activity
1.2 Proposed Biosynthesis
2 Synthetic Studies toward the Myrioneuron Alkaloids
2.1 Total Synthesis of Myrioxazines A and B
2.2 Total Synthesis of Myrionine, Myrionidine, and Schoberine
2.3 Total Synthesis of Myrifabrals A and B
2.4 Total Synthesis of Myrioneurinol
3 Conclusions and Outlook
Publication History
Received: 24 March 2023
Accepted after revision: 03 May 2023
Accepted Manuscript online:
03 May 2023
Article published online:
12 June 2023
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For isolations, see: