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DOI: 10.1055/a-2272-8163
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Carbohydrate Chemistry in China

Fragments Synthesis of A. baumannii ATCC 17961 O-Antigen

Xinxin Li
,
Liangshen Duan
,
Deyong Liu
,
Jianying Qi
,
Liming Wang∗
,
Qingju Zhang  ∗
This work was financially supported by the National Natural Science Foundation of China (22377043, 22167015, 22267010) and the Jiangxi Provincial Department of Science and Technology (jxsq2020101084, 20224ACB213006, 20212ACB213005).
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Abstract

Acinetobacter baumannii can cause many diseases including septicemia, pneumonia, meningitis, soft tissue, and urinary tract infections. Herein, we described the synthesis of one trisaccharide and two tetrasaccharide fragments derived from A. baumannii ATCC 17961 O-antigen that can be used for screening novel glyco-epitopes and for developing a synthetic carbohydrate-based vaccine against A. baumannii infection. The overall yields for the synthesis of the desired trisaccharide 1, tetrasaccharide 2, and tetrasaccharide 3 are 26.8% (8 steps), 21.6% (9 steps), and 24.5% (6 steps), respectively.

Key words

Acinetobacter baumannii 17961 - oligosaccharides - synthesis - glyco-epitopes - carbohydrate-based vaccines

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2272-8163.
  • Supporting Information


Publication History

Received: 28 December 2023

Accepted after revision: 20 February 2024

Accepted Manuscript online:
20 February 2024

Article published online:
04 March 2024

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