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Planta Med 2017; 83(07): 631-635
DOI: 10.1055/s-0042-120545
DOI: 10.1055/s-0042-120545
Biological and Pharmacological Activity
Original Papers
Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity
Further Information
Publication History
received 28 August 2016
revised 28 October 2016
accepted 04 November 2016
Publication Date:
16 November 2016 (online)
Abstract
Four new naphthoquinones (1–4), including a dimeric one, shikometabolin G (1), together with six known ones (6–10), were isolated from the methanol extract of Onosma paniculatum. Their structures were established based on the analysis of NMR and MS spectroscopic data. All of the compounds were evaluated for inhibitory effects on NO production in murine macrophage RAW 264.7 cells. Compounds 2, 3, 5, 6, 7, 8, and 10 displayed good activity on the inhibition of NO production (IC50 = 0.4–16.5 µM), suggesting the potential property of anti-inflammation.
* These two authors contributed equally to this work.
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