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Synthesis
DOI: 10.1055/s-0042-1751577
DOI: 10.1055/s-0042-1751577
paper
Base-Mediated Synthesis of 2-Bromobenzoheterocycles
R.A. thanks the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Walter Sumner Memorial for a fellowship. B.M. thanks NSERC for funding (CGS-D).
Abstract
A base-mediated cyclization to synthesize 2-bromobenzoheterocycles is reported. This transformation was demonstrated with 16 examples to access a broad range of brominated benzoheterocycles. Mechanistic studies support the reaction proceeds through a bromoalkyne, and revealed an exchangeable proton at C3 of the indole products.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751577.
- Supporting Information
Publication History
Received: 12 February 2024
Accepted after revision: 11 March 2024
Article published online:
02 April 2024
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