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Synthesis
DOI: 10.1055/a-2630-0589
DOI: 10.1055/a-2630-0589
short review
Enantioselective Copper-Catalyzed Allylic/Propargylic Acyloxylation: Asymmetric Variants of the Kharasch–Sosnovsky Reaction
Supported by: National Natural Science Foundation of China 22371119
Abstract
Copper-catalyzed enantioselective allylic/propargylic acyloxylation, evolving from the classical Kharasch–Sosnovsky reaction, has emerged as a versatile strategy for the stereocontrolled synthesis of chiral esters. This short review comprehensively summarizes recent advances in asymmetric variants of Kharasch–Sosnovsky reaction across three primary substrate categories: cyclic olefins, acyclic alkenes/alkynes, and 1,3-dienes/enynes, with particular emphasis on substrate scope and mechanistic insights.
Keywords
Asymmetric catalysis - Copper - Kharasch–Sosnovsky oxidation - Allylic - Propargylic - AcyloxylationPublication History
Received: 08 May 2025
Accepted after revision: 06 June 2025
Accepted Manuscript online:
06 June 2025
Article published online:
22 July 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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