DOI: 10.1055/s-00000131

Synfacts

Issue 05 · Volume 20 · May 2024 DOI: 10.1055/s-014-59482

Synform

A071
Zanda, Matteo: SYNFORM ISSUE 2024/05

Synthesis of Natural Products

z0447
All PDFs of this category
0447
Total Synthesis of (–)-Hunterine A
0448
Syntheses of (–)-Nidulalin A and (–)-Nidulaxanthone A
0449
Total Synthesis of Securamine D
0450
Synthesis of (+)-Principinol B
0451
Total Synthesis of (–)-Psammaplysin A
0452
Total Synthesis of (+)-Penicibilaenes A and B
0453
Synthesis of (±)-Gelsemine

Synthesis of Heterocycles

z0455
All PDFs of this category
0455
Spiro-Substituted Dioxetane-Based Chemical Probes with Enhanced Detection and Sensitivity Limits
0456
Palladium-Mediated Diastereoselective Functionalization of Cyrene
0457
Mild Nitrogen-to-Carbon Transmutation of Azaarene N-Oxides
0458
Using Metallaphotoredox Towards the Synthesis of Aryl Nitriles and α-Aryl Nitriles
0459
Access to and Physicochemical Analysis of Fluorinated Saturated Bicyclic Amine Building Blocks
0460
Synthesis of Quinolones from Propargylic Chlorides and Amines
0461
Electrochemical Formal C–H/C–H Regioselective Coupling of Heteroarenes
0462
Copper-Catalyzed Synthesis of N-Heterocyclic Bicycles
0463
Skeletal Editing of Pyridines to Afford 1,2-Diazepines
0464
Electrochemical Cross-Dehydrogenative of Amides and Heteroarenes
0465
Tether-Controlled Regiochemical Access to Complex Polyheterocyclic Molecular Architectures

Synthesis of Materials and Unnatural Products

z0467
All PDFs of this category
0467
First Stable σ0π2 Carbene
0468
BN-Heterocycles from N-Heterocycle Editing
0469
Stabilizing Acenes with Macrocycle Shielding
0470
Biaryl Ligation Promoted by Catalyst-based π–π Stacking
0471
Unsymmetric Macrocycle from Post-Modification of Dynamic Covalent Synthesis
0472
Metalla-dehydro[11]annulenes from [10+1] Reactions
0473
Azahomocorannulene Cation and Radical
0474
Convertible Polyphenylene Covalent Organic Frameworks
0475
Single-Crystal Ladder Polymer with Double Dynamic Covalent Linkers
0476
Heptagon-embedded Highly Curved Diaza[7]helicenes
0477
Acid-Triggered RAFT Polymerization
0478
Spirobifluorenes from Biaryls and Fluorenones

Metals in Synthesis

z0479
All PDFs of this category
0479
Hydrohalogenation of Alkenes Using Collidine·HX Salts under Dual Cobalt and Photoredox Catalysis
0480
Hydrofluorination of Alkenes Using Et3N·HF under Dual Cobalt and Photoredox Catalysis
0481
Stereoselective Cu-Catalyzed Hydroborylation and Hydrosilylation of Spirocyclopropenes
0482
Making Allylamines by 1,4-Aminoarylation of Butadienes under Photoinduced Palladium Catalysis
0483
Cross-Electrophile Coupling Enabled by Visible-Light Palladium Catalysis
0484
Copper-Catalyzed Crystallization-Induced Deracemization of Atropisomeric BINOL Derivatives
0485
Cobalt-Catalyzed Hydrogenation and Deuteration of Bicyclic Olefins
0486
Copper-Catalyzed Cross-Coupling of Benzyl Halides with (Me4N)SCF3
0487
Asymmetric Synthesis of α-Aryl Amides Using Nickel/Photoredox Catalysis
0488
C(sp3)–H Borylation of Alkanes and Silanes under Photoelectrochemically Driven Iron Catalysis
0489
Dialkylation of Alkenes with Aliphatic Alcohols and Alkyl Halides by Dual Nickel and Photoredox Catalysis
0490
Visible Light/Cu-Catalyzed Four-Component Alkene Azido­sulfonylation Using DABSO and Arylthianthrenium Salts
0491
Cobalt-Catalyzed Hydrosilylation of 1,6-Diynes via an Oxidative Cyclization
0492
Iridium-Catalyzed Asymmetric Silylation of Propargylic C(sp3)–H Bonds
0493
Asymmetric Synthesis of 1,3-Cyclohexadienes Enabled by Pd/Chiral Phosphoric Acid Cooperative Catalysis
0494
Azidation and Etherification of Remote C(sp2)–C(sp3) Bonds of Amines Involving 1,4-Aryl Migration
0495
Access to Axially Chiral N‑Arylindoles via Palladium-Catalyzed Atroposelective Larock Indole Synthesis
0496
Access to Highly Functionalized Cyclohexanes via a Silver-Catalyzed Double Desymmetrization
0497
Asymmetric α-C(sp3)–H Allylic Alkylation of Primary Alkylamines by Merging Iridium and Ketone Catalysis
0498
Ni-Catalyzed Electroreductive Decarboxylative Cross-Coupling of Redox-Active Esters and Oxime Esters
0499
Synthesis of N-Aryl Sulfonamides Enabled by Visible-Light Nickel Catalysis
0500
Synthesis of C(sp3)-Rich Carbonyl-Containing Scaffolds via Ni-Catalyzed Deaminative Alkyl-Alkyl Cross-Coupling
0501
Merging Decatungstate-Photocatalyzed Carbonylation of Alkanes and Asymmetric Brønsted Acid Catalysis
0502
Deoxygenative Coupling of Carbonyl Compounds with Alkynes under Molybdenum Catalysis
0503
Pd-Catalyzed Synthesis of Hydropyrrole-Containing Spirocycles via Domino Isonitrile Insertion/Heck Reactions
0504
Asymmetric Photocycloaddition of 2-Acetonaphthones
0505
Cobalt-Mediated Intramolecular Cyclization of Bis-homoallylic Alcohols under Aerobic Conditions

Polymer-Supported Synthesis

z0507
All PDFs of this category
0507
Oxidative Homo-Coupling of Benzyamines Using Multi-Motif Molecule-Based COFs
0508
Oxidation, Halogenation and Diels–Alder Reaction Promoted by a Covalent Triazine Framework
0509
Asymmetric α-Arylation of Aldehydes with Aminophenol by 2D Chiral COF
0510
N-Alkylation of Primary Amides with Alcohols Catalyzed by Cobalt Nanoparticles
0511
Low-Valent Platinum Single-Atom Catalyst for Hydrosilylation of Alkenes
0512
Selective Hydrogenation of Benzofurans Catalyzed by Pd–Ru Bimetallic Nanoparticles
0513
Hydrogenation of Chlorobenzenes and Nitrobenzenes Using Au–Pd Bimetallic NPs Supported on COF
0514
Quinoline-Linked COF for the Photocatalytic Oxidative Decarboxylation and Homo-Coupling Reactions
0515
C–O, C–S, and C–P Coupling of Aryl Halides by a Ni(II)-Incorporated Covalent Organic Framework
0516
Photoreduction of Nitrogroups via a Self-Assembled TiO2-TEOA-Nitroarenes Complex
0517
Trisindole Synthesis through a Graphene Oxide-Catalyzed Carbene-Transfer Reaction

Organo- and Biocatalysis

z0519
All PDFs of this category
0519
Organocatalytic Nucleophilic Desymmetrization of P(V) Precursors
0520
Flavin-Photocatalytic Sulfide α-C–H Functionalization Using Arylsulfonyl Multiple-Bond Reagents
0521
Diazaphospholene Hydrides Catalyze Enantioselective Reductive Eschenmoser–Claisen Rearrangements
0522
Organocatalytic Photoinduced Diastereoselective 1,2-Sulfonylsulfination of Alkenes
0523
Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation
0524
Stereoselective Synthesis of α-Aminonitriles, Catalyzed by Hydrogen-Bonding Donors
0525
Enzymatic Cleavage of Silicon–Carbon Bonds in Siloxanes
0526
Mesoionic N-Heterocyclic Olefin Catalyzes Formylation of Thiols via CO2 Trapping
0527
Enantioselective Control Over α-Iminonitriles with a Novel Bifunctional Superbase-Thiourea Organocatalyst

Innovative Drug Discovery and Development

z0529
All PDFs of this category
0529
A Convergent and Short Synthesis of Sorbicillactone A
0530
Brain Biodistribution in Non-Human Primates of [11C]BIIB104, an AMPA Receptor PAM
0531
CVN766, the Selective Orexin-1-Receptor Antagonist Progressed to Clinical Investigations
0532
One-Pot, Palladium-Free Access to 1° and 2° Amines
0533
Access to Buchwald–Hartwig Products by ‘NH’ Insertion of Suzuki–Miyaura Aryl Partners
0534
Arenophile Cycloaddition-Mediated Dearomative Pyridine Oxidation
0535
Converting 14N-Pyridines to 15N-Pyridines through Zincke Imine Intermediates
0536
From Racemic Mixtures to Enantioenriched Molecules: Suzuki–Miyaura Arylation of Acyclic Allylic Systems
0537
Accelerated Photochemical Reactions at Oil-Water Interface Exploiting Melting Point Depression
0538
Carbene-Catalyzed Alkylation of Indoles
0539
A Mild Sulfation Strategy for Alcohols
0540
Organo-Click Reaction Enables Access to Anti­malarial Derivatives of Artemisinin
0541
Parallel Synthesis of PROTACs via Photochemical C(sp2)–C(sp3) Cross-Coupling
0542
An Asymmetric Synthesis of Sulfoximines, Sulfonimidamides and Sulfonimidoyl Fluorides
0543
Schwartz’s Regent as a Chemo- and Diastereoselective Reductant of Sulfinyl Ketimines to Yield Chiral Amines
0544
Total Synthesis and SAR Studies of the Neurotrophic Sesquiterpenoid Jiadifenin

Peptide Chemistry

z0545
All PDFs of this category
0545
Dehydrative Peptide Coupling Promoted by HBF4/MS 5Å
0546
Synthesis of Functionalized Amino Acids from Cysteine Pentafluoropyridine
0547
Chiral Ru-Li Combined Catalysts for Asymmetric Cyanation of α-Ketimino Ester Derivatives
0548
Unprotected Cyclic Peptide Methylene Dithioacetals Synthesis by Rhodium Catalysis
0549
Synthesis of α,α-Dialkyl Amino Acid Ethyl Esters Using Asymmetric Phase-Transfer Alkylation
0550
Copper-Catalyzed C(sp3)–H Alkylation of Glycine Derivatives
0551
Activation of N-Ts Amide C–N Bonds by N-Heterocyclic Carbene-Squaramide Bifunctional Catalyst
0552
One-Pot Protocol to Access Spirocyclic Unnatural β-Amino Acids via C–H Activation/C–C Cleavage
0553
Synthesis of β-Tertiary Amino Acids Analogues via Cobalt-Catalyzed Stereoselective Radical Addition
0554
Copper-Catalyzed [3+2] Cycloaddition for the Site-Specific Modification of Peptides
0555
Photoredox and Nickel-Catalyzed Glycosylation of Amino Acids and Peptides
0556
Synthesis of Optically Active Amino Amides
0557
Racemization-Free Synthesis of N-Formyl Amino Acid Esters

Flow Chemistry

z0559
All PDFs of this category
0559
Synthesis of Pentafluorosulfanylpyrazoles in Flow