Synthesis

Category: Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

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Issue 04/2024

Qin, Yang; Liu, Sheng; Shi, Shi-Liang: Transition-Metal-Free Cross-Coupling of Acetals and Grignard Reagents To Form Diarylmethyl Alkyl Ethers and Triarylmethanes
https://www.thieme-connect.de/media/synthesis/202404/i_b0141_ga_10-1055_a-2088-5000.gif
Khan, Farooq-Ahmad; Yaqoob, Sana; Qasim, Muhammad Wasim; Ali, Shujaat; Wang, Yan; Jiang, Zi-Hua: A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation
https://www.thieme-connect.de/media/synthesis/202404/i_b0528_ga_10-1055_a-2004-5883.gif
Chaskar, Sudhir P.; Honparkhe, Ramchandra; Aghao, Arvind K.; Thorat, Rakesh G.; Pramanik, Chinmoy: An Alternative Formal Synthesis of (S)-(+)-Vigabatrin
https://www.thieme-connect.de/media/synthesis/202404/i_c0128_ga_10-1055_s-0042-1751470.gif
Chen, Yang; Li, Qiao-Yue; Xie, Xiao-Yan; Wang, Wei; Li, Dashan; Wang, Wen-Jing; Shao, Li-Dong: Construction of an Epoxy-lactone Moiety on the C/D Ring of Highly Oxygenated Triterpenes through a Modified SeO2-Promoted Oxidative Cyclization
https://www.thieme-connect.de/media/synthesis/202404/i_c0152_ga_10-1055_a-2122-4021.gif
Varga, Petra Regina; Belovics, Alexandra; Karaghiosoff, Konstantin; Szabó, Rita; Bősze, Szilvia; Drahos, László; Keglevich, György: Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides
https://www.thieme-connect.de/media/synthesis/202404/i_c0184_ga_10-1055_a-2122-4178.gif
Cui, Hai-Bo; Ma, Ting; Zhang, Ru-Yue; Shan, Jing; Wang, Zhong-Qiang; Bai, Mei; Chen, Yong-Zheng: Biocatalytic Synthesis of Chiral Benzylic Alcohols via Enantioselective Hydroxylation by a Self-Sufficient Cytochrome P450 from Deinococcus gobiensis
https://www.thieme-connect.de/media/synthesis/202404/i_g0096_ga_10-1055_a-2076-9792.gif
Kumar, Kankanala Naveen; Mhate, Mouzma; Ravichandiran, Velayutham; Swain, Sharada Prasanna: Bis(pinacoloto)diboron/4-Phenylpyridine System for One-Pot Photocatalyzed Borylation and Reduction of Aldehyde: Synthesis of Tavaborole in a Flow Reactor
https://www.thieme-connect.de/media/synthesis/202404/i_g0318_ga_10-1055_a-2169-6200.gif
Tintori, Guillaume; Jacob, Clément; Delsarte, Christine; Potié, François; Grimaud, Laurence; Vitale, Maxime; Echeverria, Pierre-Georges: Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction
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Bera, Shyamal Kanti; Bhanja, Rosalin; Sahu, Chandan Chittapriya; Mal, Prasenjit: An Intramolecular Radical C–N Coupling by N-Iodosuccinimide
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Nakahara, Yuichi; Endo, Yuta; Takahashi, Kazutoshi; Kawaguchi, Tomoko; Kato, Keisuke; Matsuda, Yutaka; Nagaki, Aiichiro: A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production
https://www.thieme-connect.de/media/synthesis/202404/i_m0093_ga_10-1055_a-2077-6187.gif
Ramu, Chennam; Kumaraguru, T.; Reddy, M. Sridhar; Rode, Haridas B.; Ghosh, Subhash; Reddy, Ch. Raji; Sudhakar, Gangarajula: Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
https://www.thieme-connect.de/media/synthesis/202404/i_m0494_ga_10-1055_s-0042-1751437.gif
Sunny, Steeva; Maingle, Mohit; Sheeba, Loddipalle; Pathan, Firojkhan Rajekhan; J., Gowri Sankar; Juloori, Harika; Gadewar, Sainath Ganesh; Seth, Kapileswar: Pd-Nanoparticles-Catalyzed C(sp2)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects
https://www.thieme-connect.de/media/synthesis/202404/i_r0041_ga_10-1055_a-2060-3488.gif
Zhang, Fei; Zhou, Yong; Wang, Shuangqiang; Zhao, Yao; Wu, Xiaojin; Chen, Rizhi: Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction
https://www.thieme-connect.de/media/synthesis/202404/i_b0222_ga_10-1055_a-2119-5236.gif
Ohashi, Eisaku; Sahara, Naoto; Hirano, Yoichi; Hosoya, Masahiro; Takahashi, Yusaku; Tsuno, Naoki: An Effective Additive for Introducing the Triazole Unit of Ensitrelvir: Combination of LiCl and Et3N to Easily Generate Lithium Triazinolate
https://www.thieme-connect.de/media/synthesis/202404/i_c0088_ga_10-1055_a-2085-6342.gif
Mahajan, Bhushan; Aand, Dnyaneshwar; Purwa, Mandeep; Mujawar, Taufiqueahmed; Ghosh, Subhash; Pabbaraja, Srihari; Singh, Ajay K.: Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis
https://www.thieme-connect.de/media/synthesis/202404/i_c0518_ga_10-1055_a-2022-2063.gif
Adaoudi, Omaïma; Le Bescont, Julie; Bruneau-Voisine, Antoine; Evano, Gwilherm: Copper-Catalyzed Carbonylative Cross-Coupling of Alkyl Iodides with Alcohols and Sodium Hydroxide: Synthesis of Esters and Carboxylic Acids
https://www.thieme-connect.de/media/synthesis/202404/i_m0029_ga_10-1055_a-2042-3417.gif
Dash, Rupashri; Hota, Sudhir Kumar; Murarka, Sandip: Base-Promoted 1,6-Aza-Michael Addition of Azauracils to para-Quinone Methides
https://www.thieme-connect.de/media/synthesis/202404/i_m0215_ga_10-1055_a-2104-5943.gif
Algera, Russell F.; Davidson, Andrew; Herbert, David K.; Lian, Yajing; Liu, Fangfang; Liu, Yiyang; Nematalla, Asaad; Piper, Jared L.; Magano, Javier; Monfette, Sebastien; Nguyen, Bao; Raggon, Jeffrey W.; Rainville, Joseph P.; Rane, Anil; Tao, Yong; Wang, Ke; Yayla, Hatice G.: Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling
https://www.thieme-connect.de/media/synthesis/202404/i_m0254_ga_10-1055_s-0040-1720087.gif
Das, Soumyadip; Chanda, Kaushik: One-Pot Telescopic Approach to Synthesize Disubstituted Benz­imidazoles in Deep Eutectic Solvent
https://www.thieme-connect.de/media/synthesis/202404/i_t0135_ga_10-1055_a-2102-1192.jpg