Thieme E-Books & E-Journals - Zeitschrift für Gastroenterologie / Issue

P4_01

Abdullah, Z; Trebicka, J; Knolle, PA: Functional exhaustion of virus specific CD8+ T-cell immunity in fibrotic liver leads to viral persistence

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P4_02

Bakshi, R; Heidrich, B; Calle Serrano, B; Pothakamuri, SV; Manns, MP; Wedemeyer, H; Cornberg, M; Schlaphoff, V: Hepatitis C virus (HCV)-specific CD8 T-cells in HCV-seronegative individuals: Frequency and T-cell receptor repertoire (TCR)

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P4_03

Bauer, T; Wenzel, JJ; Huber, B; Jilg, W: HBsAg-specific regulatory T cells are present in patients with chronic HBV infection

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P4_04

Berg, T; Buggisch, P; Malinski, P; Diepolder, H; Mauss, S; Rasenack, J; Goeser, T; Schmidt, WE; Kauffman, R; Beumont-Mauviel, M; Decker-Burgard, S; Zeuzem, S: Treatment of Genotype 1 HCV Treatment-Naïve Patients: final results of phase III study ADVANCE

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P4_05

Böttcher, J; Hegenbarth, S; Stabenow, D; Busch, DH; van Endert, P; Kolanus, W; Kurts, C; Schultze, JL; Diehl, L; Knolle, PA: A novel memory function of tolerant CD8+ T cells in anti-microbial immunity

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P4_06

Bröring, R; Real, C; Jahn-Hofmann, K; Ickenstein, L; John, M; Kleinehr, K; Gerken, G; Schlaak, JF: The non-specific activation of liver tissue by siRNAs in vivo can be controlled by chemical ribose modifications of siRNAs

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P4_07

Bröring, R; Kleinehr, K; Paul, A; Gerken, G; Schlaak, JF: The production of interferons is not impaired in primary isolated liver cells from HCV-positive individuals after Toll-like receptor mediated stimulation

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P4_08

Burghardt, S; Erhardt, A; Tiegs, G: The role of non-professional liver APCs for tolerance induction in the mouse model of concanavalin A-induced liver injury

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P4_09

Calle Serrano, B; Jaroszewicz, J; Heidrich, B; Grabowski, J; Bremer, B; Deterding, K; Cornberg, M; Manns, MP; Wedemeyer, H: The role of HDV in the natural history of the persistent HBV infection

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P4_10

Carambia, A; Frenzel, C; Schwinge, D; Schramm, C; Lohse, AW; Herkel, J: Liver Sinusoidal Endothelial Cells inhibit inflammatory cytokine responses of CD4 T cells through skewed accesory signals

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P4_11

Claass, B; Erhardt, A; Tiegs, G: Immune regulation in response to ConA-induced liver injury is mediated by regulatory T cells induced in dependence of IFNgamma

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P4_12

Dietz, J; Lutz, T; Knecht, G; Gute, P; Füller, C; Raziorrouh, B; Diepolder, H; Hofmann, WP; Zeuzem, S; Sarrazin, C: Sequenz-Evolution des HCV NS3/4A Protease Gens im Verlauf der akuten Hepatitis C Virus (HCV) Infektion

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P4_13

Dorloff, C; Hemberger, J; Odenthal, M; Holzmann, H; Aberle, S; Drebber, U; Dienes, HP: Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

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P4_14

Ehser, J; Holdener, M; Hintermann, E; Christen, U: Molecular mimicry rather than identity breaks T cell tolerance in a mouse model for autoimmune hepatitis

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P4_15

Eisenhardt, M; Glässner, A; Krämer, B; Körner, C; Sauerbruch, T; Spengler, U; Nattermann, J: HCV-Core-induzierte Sekretion von CXCL10 führt zur Rekrutierung CXCR3(+) Natürlicher Killer-Zellen mit geringer zytotoxischer Aktivität

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P4_16

Elanjimattom, S; Vermehren, J; Berger, A; Marzi, I; Lehmann, R; Hintereder, G; Zeuzem, S; Sarrazin, C: Hohe Prävalenz von Hepatitis C Virus-Antikörpern bei Patienten in der Zentralen Notaufnahme der J.W. Goethe Universitätsklinik, Frankfurt am Main

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P4_17

Eurich, D; Boas-Knoop, S; Neuhaus, R; Somasundaram, R; Rühl, M; Neumann, UP; Neuhaus, P; Bahra, M; Seehofer, D: Association of Mannose-Binding-Lectin-2-gene Polymorphism to the Development of Hepatitis-C-induced Hepatocellular Carcinoma

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P4_18

Farag, MMS; Tedjokusumo, R; Flechtenmacher, C; Asen, T; Stremmel, W; Protzer, U; Weigand, K: Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with Dendritic Cells pulsed by HBVsvp

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P4_19

Farag, MMS; Weigand, K; Encke, J; Momburg, F: Activation of Natural Killer Cells by Hepatitis C Virus particles in vitro

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P4_20

Gärtner, K; Stabenow, D; Odenthal, M; Arnold, B; Hämmerling, G; Protzer, U; Dienes, HP; Kurts, C; Krönke, M; Knolle, PA: A novel non-MHC-I restricted CTL effector function mediated by TNF and XIAP

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P4_21

Glässner, A; Eisenhardt, M; Krämer, B; Körner, C; Sauerbruch, T; Spengler, U; Nattermann, J: Natürliche Killer-Zellen aus HCV-infizierten Patienten induzieren effektiv Apoptose von aktivierten primären humanen hepatischen Sternzellen

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P4_22

Goeser, T; Buggisch, P; Mauss, S; Rasenack, J; Wedemeyer, H; Decker-Burgard, S; Serfaty, L: No Impact of Insulin Resistance on Antiviral Efficacy of Telaprevir-based regimen in HCV Genotype 1 Treatment-Naive Patients: Subanalysis of C208 Study

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P4_23

Grimm, D; Neumann-Haefelin, C; Kersting, N; Blum, HE; Thimme, R: IL28B genotype and hepatitis C virus specific T cell response

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P4_24

Grünhage, F; Weber, S; Mahler, M; Lammert, F: Influence of a genetic variant in the Duffy Antigen Receptor for Chemokines (DARC) on chronic liver diseases

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P4_25

Hintermann, E; Bayer, M; Christen, U: Hepatic fibrosis in the CYP2D6 mouse model for autoimmune hepatitis

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P4_26

Katt, J; Sobottka, I; Schwinge, D; Herkel, J; Lohse, AW; Schramm, C: Mikrobielle Stimulation und Toll-like-Rezeptor-Liganden bewirken eine verstärkte IL-17 Antwort in Patienten mit Primär Sklerosierender Cholangitis

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P4_27

Kittner, JM; Sprinzl, MF; Grambihler, A; Weinmann, A; Galle, PR; Schuchmann, M: Adding peg-interferon to a fully suppressive nucleos(t)ide regimen leads to rapid decrease of quantitative HBsAg in some hepatitis B patients

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P4_28

Körner, C; Riesner, K; Krämer, B; Eisenhardt, M; Glässner, A; Sauerbruch, T; Nattermann, J; Spengler, U; Nischalke, HD: Die TRAIL-Rezeptor I-Polymorphismen C626G und A638C sind mit dem Auftreten eines hepatozellulären Karzinoms (HCC) bei chronischer Hepatitis C assoziiert

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P4_29

Krämer, B; Körner, C; Eisenhardt, M; Glässner, A; Zwank, C; Sauerbruch, T; Spengler, U; Nattermann, J: Der NKp46High Phänotyp definiert eine NK Zellpopulation mit hoher zytolytischer Aktivität, die möglicherweise in die Kontrolle der HCV-Replikation involviert ist

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P4_30

Lütgehetmann, M; Bornscheuer, T; Volz, T; Allweiss, L; Lohse, A; Petersen, J; Dandri, M: Hepatitis B virus Infection inhibits responsiveness to interferon alpha treatment in human hepatocytes in vivo

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P4_31

Lutz, P; Wasmuth, JC; Nischalke, HD; Vidovic, N; Grünhage, F; Lammert, F; Oldenburg, J; Rockstroh, JK; Sauerbruch, T; Spengler, U: Der rs12979860 C/T-Polymorphismus des IL28B-Gen beeinflusst die Progression der Leberfibrose bei HIV positiven Patienten mit HCV Genotyp 1 Koinfektion

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P4_32

Mertens, JC; Baur, K; Schmitt, J; Iwata, R; Stieger, B; Frei, P; Al-Deb'i, A; Seifert, B; Müllhaupt, B; Geier, A: Common Vitamin D Receptor (NR 1I1) gene polymorphisms and 25-OH vitamin D serum levels influence fibrosis progression and hepatic MMP-9 expression in chronic hepatitis C patients

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P4_33

Müllenbach, R; Weber, S; Zimmer, V; Krawczyk, M; Lammert, F; Grünhage, F: The common bile salt transporter polymorphism ABCB11C.1331T>C is associated with HCV infection but not with increased liver stiffness in a german cohort: Mechanistical implications

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P4_34

Nattermann, J; Timm, J; Nischalke, HD; Olbrich, A; Berg, T; Wedemeyer, H; Wiese, M; Roggendorf, M; Sauerbruch, T; Spengler, U: Einfluss des CCR5D32 Genotyps auf spontanen Verlauf der HCV-Infektion und prädiktiven Wert des IL28B-Polymorphismus in der Ostdeutschen Anti-D-Kohorte

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P4_35

Peiseler, M; Sebode, M; Franke, B; Wortmann, F; Quaas, A; Schwinge, D; Weiler-Normann, C; Lohse, AW; Schramm, C; Herkel, J: The frequencies of Foxp3+ regulatory T cells in livers and peripheral blood of type I autoimmune hepatitis patients correlate with inflammatory activity

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P4_36

Preiß, J; Wenzel, JJ; Schemmerer, M; Huber, B; Jilg, W: Detection and Characterization of Hepatitis E Virus from Pig Livers Sold in Local Butcher Shops in Southeastern Germany – A Possible Source of Infection for Humans?

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P4_37

Resheq, Y; Lüth, S: Niedrige Frequenz IgG4+Plasmazellen in der Leber bei autoimmunen Lebererkrankungen

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P4_38

Ruhl, M; Knuschke, T; Schewior, K; Wiese, M; Tenckhoff, H; Spengler, U; Nattermann, J; Hoffmann, D; Timm, J: CD8+ T cell selection pressure is a major driving force for evolution of hepatitis C virus nonstructural proteins

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P4_39

Schildberg, FA; Wojtalla, A; Siegmund, SV; Diehl, L; Kurts, C; Knolle, PA: Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

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P4_40

Schlaphoff, V; Lunemann, S; Pothakamuri, SV; Jaroszewicz, J; Grabowski, J; Pischke, S; Helfritz, FA; Manns, MP; Cornberg, M; Wedemeyer, H: The association of 2B4 up-regulation and SAP down-regulation indicates exhaustion of virus-specific CD8+ T cells

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P4_41

Schmidt, J; Wunsch, K; Kuntzen, T; Oniangue-Ndza, C; Allen, TM; Thimme, R; Neumann-Haefelin, C: Protection from persistent hepatitis C virus infection by HLA class I: The need for multiple escape mutations in immunodominant T cell epitopes is a common feature

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P4_42

Seigel, B; Bengsch, B; Lohmann, V; Blum, HE; Thimme, R: Ex vivo analysis of HCV-specific CD8+ T cell antiviral efficacy using a novel immunological model

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P4_43

Sprinzl, K; Vermehren, J; Elanjimattom, S; Farnik, H; Zeuzem, S; Sarrazin, C: Erfolgsadaptierte Therapie mit Lamivudin – eine Option auf langfristige Virussuppression im selektierten HBV-Patientenkollektiv

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P4_44

Sprinzl, MF; Bührer, L; Strand, D; Schreiber, G; Galle, PR; Piehler, J; Schuchmann, M: Antiproliferative and antiviral effects of mutated IFN-alpha with increased IFN receptor binding affinity

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P4_45

Sun, LA; Steinebrunner, N; Joschko, N; Langhein, A; Stremmel, W; Protzer, U; Müller-Schilling, M: The p53 family is involved in the elimination of Hepatitis B virus (HBV)-infected hepatocytes

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P4_46

Timm, B; Wahl, A; Blum, HE; Moradpour, D; Brass, V: Screening for Hepatitis C Virus (HCV) protein interactions by the use of intergenotypic replicon chimeras

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P4_47

Volz, T; Allweiss, L; Lütgehetmann, M; Lohse, A; Matthes, E; Petersen, J; Dandri, M: Strong in vivo antiviral efficacy of a new L-deoxycytidine derivate in hepatitis B virus infected chimeric uPA mice

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P4_48

Wenzel, JJ; Preiß, J; Schemmerer, M; Huber, B; Jilg, W: Seroprevalence of Anti-Hepatitis E Virus (HEV) IgG in Southeastern Germany and Comparison of Three Commercial Anti-HEV IgG Tests

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V4_01

Arrenberg, PG; Maricic, I; Lohse, AW; Kumar, V: Aktivierung von Typ II Natürlichen Killer T Zellen schützt vor ischämischem Reperfusionsschaden der Leber

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V4_02

Reiss, S; Rebhan, I; Backes, P; Longerich, T; Schirmacher, P; Bartenschlager, R; Lohmann, V: Enzymatic activity of Phosphatidyl-inositol-4 kinase III alpha (PI4KIIIα) is critically involved in HCV replication and regulated by HCV NS5A

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V4_03

Jaroszewicz, J; Ho, H; Deterding, K; Markova, A; Wursthorn, K; Tillmann, HL; Schulz, S; Bock, TC; Manns, MP; Wedemeyer, H; Cornberg, M: Relevance of quantitative HBsAg (qHBsAg) during long-term treatment of chronic hepatitis B with nucleos(t)ide analogues (NUCs)

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