Abstracts (HTML) List of Authors

Wagner-Golbs, A

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Wahlström, A

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Waidmann, O

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Waisman, A

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Walter, J

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics

Wammers, M

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Wan, S

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Wandrer, F

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Wandt, N

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Wang, B

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Wang, J

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Wang, L

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Wang, P

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Wang, S

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Ware, CF

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Weber, A

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Weber, SN

Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Weber, T

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Weber, TF

RSPO2 gene rearrangement – a new cancer driver in the liver

Wedemeyer, H

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Wehmeyer, MH

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Wei, X

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Weidemann, S

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Weigert, A

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Weiler, SE

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

Weiler, SME

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Weiler-Normann, C

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Weinmann, A

Lipid droplets and associated proteins in viral hepatitis
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Weiskirchen, R

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Weiskirchen, S

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Weiss, J

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Weiss, KH

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort
RSPO2 gene rearrangement – a new cancer driver in the liver
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Weiss, TS

Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Welsch, C

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Welsch, H

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Weng, HL

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Wenning, C

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Werner, M

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Wettengel, J

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Widera, M

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Wiecek, S

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Wiek, C

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Wieland, D

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Wild, K

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Wilhelm, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Wilhelm, D

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Willuweit, K

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Wimmer, R

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Wineberger, K

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

Wingerath, J

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Winkler, F

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Winkler, S

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Wirth, TC

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Wirtz, TH

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Wisskirchen, K

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Witt, A

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Witte, V

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Witzel, HR

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Wohlleber, D

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Woitok, MM

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Wolf, K

Lysophosphatidic acid activates peripheral glial cells

Wolf, S

Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM

Wolff, K

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Wölfl, S

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Woller, N

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Wolters, F

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Wong, HY

Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress

Wormser, L

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Wörns, M

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Wörns, MA

Steatosis and associated proteins in hepatocellular adenoma

Wöstemeier, A

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Wunderlich, T

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Wupperfeld, D

Delivery of Copper-chelating Trientine (TETA) to the central nervous system