DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 49 · January 2011 DOI: 10.1055/s-002-21608


27. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Regensburg, 28.–29. Januar 2011

Prof. Dr. Hans-Jürgen Schlitt
Abstracts (HTML) List of Authors
P2_01
Abbas, AS; Sheikh, N: Changes in the hematology, serum electrolytes and liver histology in diet induced obese rats
P2_02
Alinger, B; Di Fazio, P; Quint, K; Ocker, M; Neureiter, D: The HDAC inhibitor Panobinostat induce differentiation and reduce de-differentiation in human hepatoma xenografts
P2_03
Arndt, S; Mägdefrau, U; Dorn, C; Schardt, K; Hellerbrand, C; Bosserhoff, A: Age and gender dependent differences in BMP6 mediated hepcidin expression and iron homeostasis
P2_04
Ayub, TH; Vogt, A; Sauerbruch, T; Gonzalez-Carmona, MA: Synergistische antitumorale Wirkung von AFP-beladenen und CD40L-exprimierenden Dendritischen Zellen in etablierten hepatozellulären Tumoren in vivo
P2_05
Becker, D; Sfakianakis, I; Krupp, M; Staib, F; Victor, A; Blettner, M; Maass, T; Thorgeirsson, S; Galle, PR; Teufel, A: Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC
P2_06
Bender, MH; Koenig, LC; Joschko, N; Stremmel, W; Müller-Schilling, M: MicroRNAs are key players of the p53 pathway in hepatocellular carcinoma
P2_07
Bernsmeier, A; Schumacher, J; Bröring, D; Müller, L: Effekt von Sorafenib auf die Migrationseigenschaften humaner Tumorstroma-assoziierter Fibroblasten (TAFs) des intrahepatischen Cholangiokarzinoms (ICC)
P2_08
Böhme, I; Hempel, M; Ebensing, S; Brückner, S; Christ, B: Die Nutzung primärer Schweinehepatozyten als metabolisierendes System für In-vitro-Embryotoxizitätstests
P2_09
Borkham-Kamphorst, E; Zimmermann, HW; Karlmark, KR; Van de Leur, E; Bauer, J; Tacke, F; Weiskirchen, R: Lipocalin-2 (LCN2) in experimental liver injury and human liver diseases
P2_10
Calvisi, DF; Chen, X; Ho, C; Ladu, S; Destefanis, G; Mattu, S; Delogu, S; Thorgeirsson, SS; Dombrowski, F; Evert, M: Epigenetic and post-transcriptional mechanisms are responsible for disruption of the Hippo tumor suppressor pathway in human hepatocellular carcinoma
P2_11
Calvisi, DF; Evert, K; De Murtas, V; Gasparetti, G; Destefanis, G; Mattu, S; Dombrowski, F; Evert, M: De novo lipogenesis is required for insulin-mediated hepatocarcinogenesis and contributes to human liver cancer prognosis
P2_12
Calvisi, DF; Chen, X; Ho, C; Ladu, S; Mattu, S; Destefanis, G; Delogu, S; Dombrowski, F; Evert, M: Activation of the SKP2 protooncogene is a common effector pathway in hepatocarcinogenesis and contributes to malignant transformation of the liver
P2_13
Chamulitrat, W; Xu, W; Katava, N; Pathil, A; Stremmel, W: Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) Protects Mouse Hepatocytes from Lipoapoptosis by Upregulating Stearoyl-CoA Desaturase-1
P2_14
Chen, Y; Güldiken, N; Omary, MB; Adler, G; Haybaeck, J; Strnad, P: Verlust von Keratin 19 prädisponiert zur Entwicklung einer cholestatischen Erkrankung
P2_15
Dayoub, R; Wagner, H; Stöltzing, O; Spruss, T; Schlitt, HJ; Melter, M; Weiss, TS: Liver regeneration associated protein ALR exhibits anti-metastatic potential in hepatocellular carcinoma
P2_16
Dettmer, K; Stevens, A; Gronwald, W; Hellerbrand, C; Oefner, PJ: Mass spectrometry based metabolomics to study the development of Non-alcoholic steatohepatitis
P2_17
Di Fazio, P; Montalbano, R; Quint, K; Ocker, M: Involvement of autophagy related factors in liver cancer cells after treatment with panobinostat
P2_18
Dzieran, J; Fabian, J; Maass, T; Teufel, A; Dooley, S; Meindl-Beinker, NM: Role of TGF-beta and Smad7 in HCC development and progression
P2_19
Elfimova, N; Noetel, A; Kwiecinski, M; Winkel, N; Ommer, K; Dienes, HP; Odenthal, M: The tumor suppressor, miR-198, affects central pathways in tumorigenesis and in the immune response of hepatocellular carcinoma cells
P2_20
Ertle, J; Dechêne, A; Sowa, JP; Penndorf, V; Herzer, K; Kaiser, G; Schlaak, JF; Gerken, G; Canbay, A: Nonalcoholic Fatty Liver Disease progresses to HCC in the absence of apparent Cirrhosis
P2_21
Fabian, J; Dzieran, J; Dooley, S; Meindl-Beinker, NM: Role of TGF-β and Smad7 in apoptosis of HCC cells
P2_22
Freise, C; Erben, U; Trowitzsch-Kienast, W; Neumann, UP; Seehofer, D; Kim, K; Rühl, M; Zeitz, M; Somasundaram, R: (+)-Episesamin zeigt anti-neoplastische Effekte in humanen HCC Zelllinien durch Hemmung des IGF-1-Signalweges
P2_23
Friedrich, D; Lammert, F: Fibroblast Growth Factor 19 (FGF-19)– Verringerte postprandiale Serumspiegel bei nicht Adipösen mit nichtalkoholischer Fettlebererkrankung (NAFLD)
P2_24
Fuest, M; Willim, K; Blum, HE; Hasselblatt, P: Regulation of the hepatocellular response to endoplasmic reticulum stress by the transcription factor c-Jun/AP-1
P2_25
Galli, UM; Zöller, M; Bruns, H; Schemmer, P: Establishment of a conditional knock out mouse to investigate the function of C4.4A in liver diseases
P2_26
Ganzleben, I; Millonig, G; Longerich, T; Schirmacher, P; Seitz, HK; Mueller, S: Iron metabolism in patients with ALD
P2_27
Güldiken, N; Zhou, Q; Kucukoglu, O; Adler, G; Omary, MB; Strnad, P: Human keratin 8 variants predispose to acetaminophen toxicity
P2_28
Hagemann, GP; Fürst, M; Vollbrecht, H; Bielefeld, T; Braun, F; Günther, R: Die Interaktion von CK18 und ZAP90 in der Retinolsäure-induzierten Apoptose bei Hepatozellulären Karzinomzelllinien
P2_29
Haller, MT; Mogler, C; Aulmann, S; Lohmann, V; Brand, K; Schirmacher, P; Longerich, T: Annexin A2 as a differential diagnostic marker of hepatocellular tumors
P2_30
Hashani, M; Pawella, LM; Schirmacher, P; Straub, BK: MLDP/ perilipin 5 is a widely expressed lipid droplet-associated protein with differential localization in striated myocytes and steatotic hepatocytes
P2_31
Heim, D; Cornils, K; Fehse, B; Lohse, AW; Brümmendorf, TH; Wege, H: Applikation der retroviralen Insertionsmutagenese zur Identifikation relevanter molekularer Mechanismen in der humanen Hepatokarzinogenese
P2_32
Henkel, J; Frede, K; Püschel, GP: Stimulation der hepatischen Lipidakkumulation durch PGE2-vermittelte Hemmung von β-Oxidation und VLDL-Bildung
P2_33
Henkel, J; Elz, S; Gärtner, D; Schraplau, A; Schanze, N; Püschel, GP: Verstärkung hepatischer Insulinresistenz und Steatose durch PGE2-vermittelte Bildung von Oncostatin M
P2_34
Hernandez Valenciano, L; Lieske, S; Kuna, M; Neuschäfer-Rube, F; Pfeiffer, A; Püschel, G; Birkenfeld, A: Glucagon-stimulierte Induktion des Indy-Gens in primären Hepatozyten aus der Ratte aber nicht aus der Maus
P2_35
Herzer, K; Beilfuss, A; Kretschmann, G; Müller, S; Duenbostell, A; Sowa, J; Ertle, J; Biesterfeld, S; Gerken, G; Galle, PR; Canbay, A: Proteasomal degradation of the tumor suppressor PML supports HCC development
P2_36
Hoffmann, SA; Lübberstedt, M; Müller-Vieira, U; Knobeloch, D; Nüssler, A; Gerlach, JC; Zeilinger, K: Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system
P2_37
Hu, W; Nevzorova, YA; Moro, N; Haas, U; Barbacid, M; Trautwein, C; Liedtke, C: The Cyclin-dependent kinase 2 (Cdk2) is dispensable for liver regeneration in mice
P2_38
Ilowski, M; Lee, SML; Donabauer, B; Rentsch, M; Jauch, KW; Thasler, WE: Hepatische Wachstumsfaktoren schützen vor Ethanol induziertem Zellschaden
P2_39
Itzel, T; Krupp, M; Marquardt, J; Maass, T; Becker, D; Galle, PR; Teufel, A: Analyse Co-regulierter Gene in HCC und Vergleich zu anderen Tumorentitäten
P2_40
Jüngst, C; Eloranta, J; Kullak-Ublick, G: Human hepatic organic anion transporter 7 is negatively regulated by hepatocyte growth factor
P2_41
Kalthoff, S; Freiberg, N; Manns, MP; Strassburg, C: Hohe Frequenz funktioneller UGT1A- und ABCC2-Varianten bei Trägern des Gilbert-Meulengracht Genotyps UGT1A1*28
P2_42
Kiesslich, T; Alinger, B; Kemmerling, R; Ocker, M; Berr, F; Neureiter, D: Different expression pattern of stem cell markers in xenografts of human biliary tract cancer cell lines
P2_43
Klein, MS; Dorn, C; Saugspier, M; Hellerbrand, C; Dettmer-Wilde, K; Oefner, PJ; Gronwald, W: Discrimination of steatosis and NASH in mice using nuclear magnetic resonance spectroscopy
P2_44
Koenig, LC; Sandig, C; Bender, MH; Stremmel, W; Müller-Schilling, M: Protein protein interaction of p53 and p73 with YY1 in human hepatocellular carcinoma
P2_45
Krause, P; Doratiotto, S; Serra, MP; Marongiu, F; König, S; Laconi, E: The growth pattern of transplanted normal and nodular hepatocytes
P2_46
Krawczyk, M; Lütjohann, D; Schirin-Sokhan, R; Molina, H; Azocar, L; Nervi, F; Lammert, F; Miquel, JF: Serum cholesterol precursors and phytosterol levels indicate increased cholesterol output and biosynthesis as independent predictive risk factors of gallstones
P2_47
Krawczyk, M; Grünhage, F; Mahler, M; Tirziu, S; Acalovschi, M; Lammert, F: The common adiponutrin variant p.I148M, a genetic risk factor for non-alcoholic fatty liver disease, affects fasting glucose and triglyceride levels
P2_48
Krömer, A; Brockhoff, G; Wege, A: Humanized tumor mice–a new cutting-edge model to study immune responses in advanced cancer therapy
P2_49
Krüger, A; Lünse, S; Brühmann, C; Glanemann, M; Knobeloch, D: Einflüsse Genisteins auf den hepatischen Lipidstoffwechsel im in-vitro Steatosis-Modell
P2_50
Lee, SML; Gashi, S; Fröba, S; Jauch, KW; Thasler, WE: RNA stability in human liver: effects of different processing times, temperatures and storage methods
P2_51
Lenz, LS; Marx, J; Chamulitrat, W; Kaiser, I; Gröne, HJ; Liebish, G; Stremmel, W; Herrmann, T: Hepatic Steatosis as a Result of Altered Lipid Metabolism in Mice with Adipocyte-specific Fatp4-deficiency under High-fat Diet
P2_52
Longerich, T; Müller, MM; Breuhahn, K; Schirmacher, P; Benner, A; Heiß, C: Oncogenetic tree modeling of human hepatocarcinogenesis
P2_53
Lukowski, S; Weng, H; Dooley, S; Ilkavets, I: The proliverative role of WISP1 in hepatocellular carcinoma
P2_54
Lunova, M; Vaulont, S; Haybaeck, J; Lackner, K; Adler, G; Strnad, P: Hepcidin knockout mice as a model of iron-overload associated liver disease
P2_55
Lünse, S; Krüger, A; Brühmann, C; Glanemann, M; Knobeloch, D: Effects of Genistein on hepatic insulin signaling
P2_56
Maass, T; Westphal, H; Galle, PR; Teufel, A: Dkk2 Knock out führt zur vermehrter Hepatokarzinogenese
P2_57
Mägdefrau, U; Arndt, S; Kivorski, G; Hellerbrand, C; Bosserhoff, A: Down-regulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma
P2_58
Mahli, A; Dorn, C; Saugspier, M; Weiss, T; Thasler, W; Heilmann, J; Hellerbrand, C: The hop chalcone xanthohumol beneficially affects hepatocellular lipid metabolism
P2_59
Malz, M; Brauckhoff, A; Weber, A; Samarin, J; Riener, MO; Soll, C; Schirmacher, P; Breuhahn, K: The ubiquitin ligase SIAH-1 mediates overexpression of nucleic-acid binding protein FBP-3 and promotes HCC cell proliferation
P2_60
Millonig, G; Ganzleben, I; Casanovas, G; Peccerella, T; Seitz, HK; Muckenthaler, MU; Mueller, S: H2O2 rapidly activates the systemic iron hormone hepcidin independent of the IL-6/BMP6 network
P2_61
Mogler, C; Weng, H; Singer, S; Schirmacher, P; Longerich, T: Delta like ligand 4 expression in the endothelium of hepatocellular carcinoma is associated with poor tumor differentiation and early tumor stages
P2_62
Müller, L; Schumacher, J; Bernsmeier, A; Goumas, F; Wilms, C; Bröring, D: Funktionelle Analysen zur „Aktivierung“ von Tumor-assoziierten Fibroblasten aus kolorektalen Lebermetastasen im Vergleich zu Leberfibroblasten
P2_63
Nies, A: Expression of the organic anion transporters OATP1B1, OATP1B3, and OATP2B1 in human liver is affected by genetic and nongenetic factors
P2_64
Pawella, LM; Straub, BK; Hashani, M; Schirmacher, P: Induction and siRNA-mediated downregulation of the lipid droplet-associated PAT-proteins adipophilin and TIP47 in cell culture models of hepatocyte steatosis
P2_65
Pelz, S; Stock, P; Hempel, M; Brückner, S; Richter, K; Christ, B: Die Rolle des mikrosomalen Triglyzeridtransferprotein (MTTP) bei nahrungsinduzierter NASH im Mausmodell
P2_66
Qin, H; Glassen, K; Millonig, G; Linhart, KB; Bartsch, H; Wang, XD; Mueller, S; Seitz, HK: The role of cytochrome P-4502E1 in the development of hepatic fat, fibrosis and DNA lesions in patients with of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD)
P2_67
Raskopf, E; Sauerbruch, T; Schmitz, V: Die Gabe von siRNA-VEGF hemmt in Endothelzellen den durch Nexavar verursachten Anstieg von VEGF und verstärkt antiangiogene Effekte
P2_68
Reinartz, A; Haynes, C; Knuechel, R; Weiskirchen, R; Merrill, A; Gassler, N: Apoptosis sensitization of hepatocytes by acyl-CoA synthetase 5 involves deregulation of sphingolipid metabolism and alterations in mitochondrial signalling
P2_69
Reinehr, R; Sommerfeld, A; Häussinger, D: Insulin-induced hepatocyte proliferation involves swelling-dependent activation of the epidermal growth factor receptor
P2_70
Rifai, K; Mix, H; Krusche, S; Boozari, B; Potthoff, A; Manns, MP; Gebel, M: Keine Größenzunahme oder Komplikationen von fokal nodulären Hyperplasien (FNH) im Verlauf einer Schwangerschaft
P2_71
Rupp, C; Riedel, D; Giese, T; Reinhard, L; Weiss, KH; Kloeters-Plachky, P; Schirmacher, P; Stremmel, W; Sauer, P; Gotthardt, DN: The bile-duct bile proteome: Identification of 379 proteins and its relevance for cholestatic liver disease
P2_72
Sass, G; Sirma, H; Hashemolhosseini, S; Hellerbrand, C; Neureiter, D; Ocker, M; Tiegs, G: The kinase inhibitor DMAT reduces experimental HCC growth in mice
P2_73
Saugspier, M; Gehrig, M; Heilmann, J; Hellerbrand, C: Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells
P2_74
Schäfer, C; Lornejad-Schäfer, MR; Schröder, KR: A human hepatic 3D-cell culture model for basic research, preclinical drug metabolism and toxicity testing
P2_75
Schafmayer, C; Hinz, S; Egberts, J; von Schönfels, W; Landrock, A; Richter, A; Schreiber, S; Bröring, D; Hampe, J; Schniewind, B: Pilotstudie zu metabolomischen Signaturen elektrochirurgischer Leberpräparation
P2_76
Scheller, T; Moser, C; Wagner, C; Scheiffert, E; Geissler, E; Schlitt, HJ; Lang, SA: Inhibition von FGFR hemmt Motilität und angiogene Signaltransduktion von Tumor- und Endothelzellen im HCC Modell
P2_77
Schlagheck, JM; Godoy, P; Campos, G; Stöber, R; Hengstler, JG; Vogt, R; Melter, M; Weiss, TS: Epithelial mesenchymal Transition (EMT) associated transcription factor Goosecoid is highly expressed in human hepatocellular carcinoma (HCC)
P2_78
Schmid, A; Lau, Y; Ehnert, S; Dooley, S; Stöckle, U; Wildemann, B; Nussler, AK: MDR2-/- Mice as Model for Hepatic Osteodystrophy
P2_79
Schmitt, J; Kong, B; Stieger, B; Guo, G; Tschopp, O; Schultze, SM; Mertens, JC; Frei, P; Weber, A; Müllhaupt, B; Geier, A: Protective effects of FXR on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
P2_80
Schneider, C; Gassler, N; Huss, S; Wasmuth, HE; Luedde, T; Trautwein, C; Tacke, F: Adaptive Immunität supprimiert Hepatokarzinogenese und Tumorwachstum im murinen DEN-Modell in vivo
P2_81
Schraplau, A; Henkel, J; Wohlgemuth, F; Schweizer, U; Kluge, R; Schürmann, A; Püschel, GP: Mausstammspezifische Unterschiede in der Regulation des Energiestoffwechsels durch Aktivierung der nucleären Rezeptoren PPARα und CAR in der Leber
P2_82
Schyschka, L; Neumann, J; Mühl-Benninghaus, R; Unger, M; Stöckle, U; Ehnert, S; Nüssler, A: Darbepoetin inhibits proliferation of Huh-7 and Hep3B cells via up-regulation of the tumor-suppressor gene p53
P2_83
Sheikh, N; Naz, N; Malik, IA; Ramadori, G: Expression of Transferrin, Transferrin Receptor2 and Hephaestin genes in the models of liver injury
P2_84
Sprinzl, MF; Heise, M; Weinmann, A; Büchler, P; Galle, PR; Friess, H; Otto, G; Schuchmann, M; Protzer, U: Multi kinase inhibitor Sorafenib modulates cytokine secretion by HCC and liver tissue
P2_85
Staib, F; Karakus, M; Krupp, M; Maass, T; Galle, PR; Teufel, A: Common HCC Cell Lines Represent Only a Subgroup of Human HCC Cases
P2_86
Straub, BK; Boda-Heggemann, J; Pape, UF; Zimbelmann, R; Rickelt, S; Grund, C; Kuhn, C; Singer, S; Schirmacher, P; Franke, WW: E-/ N-cadherin cis-heterodimer-bearing puncta adhaerentia as a hallmark for epithelia and derived tumors of the hepatopancreaticobiliary system
P2_87
Sydor, S; Gu, Y; Sowa, JP; Treckmann, J; Mathé, Z; Wree, A; Rauen, U; Gerken, G; Canbay, A: Western-diet enhances expression of death receptors and fatty acid transporters in a mouse model of 70% hepatectomy and leads to increased cell proliferation in the liver
P2_88
Thomas, A; Reinders, J; Oefner, PJ: Investigation of early proteomic changes in liver affected by non-alcoholic steatohepatitis
P2_89
Tönjes, A; Strauch, T; Ruffert, C; Mössner, J; Stumvoll, M; Kovacs, P; Wittenburg, H: Genetic variation in the human interleukin 4 (IL4) gene is associated with gallstone susceptibility
P2_90
Valletta, D; Amann, T; Czech, B; Weiss, T; Bosserhoff, A; Hellerbrand, C: Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis
P2_91
Wagnerberger, S; Spruss, A; Kanuri, G; Volynets, V; Stahl, C; Bischoff, SC; Bergheim, I: Rolle der Toll-like Rezeptoren 1–9 bei der Entstehung der fruktose-induzierten hepatischen Steatose im Mausmodell
P2_92
Zellmer, S; Schmidt-Heck, W; Hengstler, JG; Guthke, R; Gebhardt, R: Regulatory modules of miRNA and transcription factors affect gene expression in cultivated hepatocytes
P2_93
Zellmer, S; Schmidt-Heck, W; Godoy, P; Weng, H; Meyer, C; Lehmann, T; Sparna, T; Schormann, W; Hammad, S; Kreutz, C; Timmer, J; von Weizsäcker, F; Thürmann, P; Merfort, I; Guthke, R; Dooley, S; Hengstler, JG; Gebhardt, R: Die zytokin-unabhängige Proliferation von Maushepatozyten wird durch die Transkriptionsfaktoren ETF, E2F and SP-1 beeinflusst
P2_94
Zimmer, V; Rusticeanu, M; Mihalache, F; Höblinger, A; Krawczyk, M; Grünhage, F; Acalovschi, M; Sauerbruch, T; Lammert, F: Bedeutung häufiger Einzelnukleotidpolymorphismen im NOD2/CARD15-Gen bei malignen Gallenwegstumoren
P2_95
Zopf, S; Di Fazio, P; Gahr, S; Strobel, D; Neurath, MF; Ocker, M: The pan-deacetylase inhibitor panobinostat (LBH 589) inhibits DNA methyltransferases in HCC in vitro and in vivo
V2_01
Hora, C; Mertens, JC; Saar, B; Kettenbach, J; Ledermann, M; Mertens, S; Dufour, JF; Geier, A: Effects of Radiofrequency Ablation (RFA) in combination with Sorafenib in a 2-Tumor Rat Model of Hepatocellular Carcinoma
V2_02
Matz, M; Gebhardt, R: Der Hedgehog Signalweg als neuer Master-Regulator des Lipidmetabolismus in Hepatocyten: Implikationen für die hepatische Steatose
V2_03
Hohenester, S; Wenniger, L; Oude Elferink, R; Beuers, U: Ein biliärer HCO3- Schirm schützt humane Cholangiozyten vor Gallensäuren-induziertem Zellschaden