28. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abdulkarim, M

Atypische Präsentation der Primär biliären Zirrhose bei Männern

Abdullah, Z

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Ackermann, K

Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

Adrian, I

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

Ahearn, AJ

Functional analysis of immunological mechanisms following mouse liver transplantation

Ahmad, G

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Ahmad, S

Changes of LCN–2 gene expression in different organs in a rat model of tissue damage

Ahrenstorf, G

Chronic hepatitis E in patients with CVID in Germany?

Alberts, R

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Albrecht, U

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Al-Debi, A

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Aleithe, S

The role of Suppressor of Fused in the regulation of Hedgehog and Wnt/ß-Catenin signaling pathway in adult liver

Alexandrov, A

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

Alinger, B

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Allgayer, S

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Allweiss, L

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Al-Malat, T

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Al Massoudi, M

JNK1 is protective for the progression of NEMO-dependent hepatitis

Al-Saeedi, M

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Al-samman, M

G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9

Alshuth, U

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Altinbas, A

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Altmüller, J

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

Amanzada, A

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

PECAM–1 (CD31)-gene expression is downregulated by TNF-α or Interferon (IFN-) but upregulated by TGF–1 in peripheral blood leukocytes

Amarapurkar, D

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Amer, W

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

Andersen, JB

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Andersson, TB

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Angel, P

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Armbruster, J

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

Armeanu-Ebinger, S

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Arndt, S

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

Arnold, N

Genetic characteristics of the human hepatic stellate cell line LX–2

Arrese, M

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Aselmann, H

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Atreya, I

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Ayata, K

P2Y2 receptor function aggravates acute hepatitis by regulating neutrophil infiltration and hepatocyte survival

Baba, HA

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Bahr, MJ

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen

Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Bahra, M

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Baier, L

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Balachandran, M

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Balagopal, A

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Bantel, H

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Bara, C

Chronic hepatitis E in heart transplant recipients

Bara, CL

HEV-specific T-cell responses are associated with control of HEV infection

Barbacid, M

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Barikbin, R

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Baron, U

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Barreiros, AP

Efficacy, safety and diagnostic accuracy of ultrasound guided biopsies of focal liver lesions: a single center experience in 214 patients

Barsotti, A

A nuclear pore component regulates select p53 target genes

Bartens, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Bartenschlager, R

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Batke, E

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Batra, A

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

Batusic, DS

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Bauer, S

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Bauer, T

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Baumgarten, A

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Baus, C

Vitamin D and depression in chronic liver disease

Bechmann, LP

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Low sodium urine concentration is associated with poor survival in patients with HRS

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Bechstein, WO

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie

Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Becker, H

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Becker, K

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Becker, M

Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

Becker, T

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Beckmann, J

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Begus-Nahrmann, Y

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Beisel, C

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Bender, M

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Beneken, C

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Bengsch, B

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection

Benten, D

Immortalisierte humane hepatische Sternzellen migrieren schädigungsspezifisch in der Mausleber und führen zu exzessiver Leberfibrose

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Benz, K

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Berchtold, S

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Berg, T

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Berger, A

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Berger, C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Bergheim, I

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Bergmann, C

Genetic characteristics of the human hepatic stellate cell line LX–2

Bernhagen, J

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Berr, F

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Berres, ML

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

Bettinger, D

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Beuers, U

Antimitochondriale Antikörper sind ungeeignet zur Diagnose der Primär Biliären Zirrhose in Mäusen

Bexten, T

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie

Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Bierhaus, A

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Birth, M

Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

Bischoff, SC

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Bissinger, M

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Bitzer, M

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Blankenstein, A

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Blaschke, M

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Blüher, M

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Blum, HE

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

Bock, M

Optimization of maturity levels of human hepatic cell lines in tissue culture

Bode, JG

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages

Boecher, WO

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Boekschoten, M

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Boesecke, C

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Boger, R

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Bohner, A

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

Komplexe genetische Determinanten der HCC-Initiation

Bonavita, C

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie

Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Boogaerts, G

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

Borkham-Kamphorst, E

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

Bösmüller, HC

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Bosserhoff, A

Expression of the atypical cadherin Fat1 in hepatic fibrosis

GLUT 1 expression favors formation and growth of hepatic metastasis

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Bossow, S

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Böttcher, G

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Böttcher, JP

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Böttger, J

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Braspenning, J

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Braun, F

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Brauner, C

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Braunschweiger, I

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C

Breitfeld, P

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

Breitkopf-Heinlein, K

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Bremer, B

Chronic hepatitis E in heart transplant recipients

HEV-specific T-cell responses are associated with control of HEV infection

Brennan, TV

Functional analysis of immunological mechanisms following mouse liver transplantation

Breuhahn, K

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Influence of IL–1β and IL–1 receptor antagonist on T-cell adhesion to hepatic endothelial cells: a potential implication for leukocyte recruitment in HCC

A nuclear pore component regulates select p53 target genes

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Brevick, L

Schlüsselrolle von PGE2 im Circulus vitiosus der Prostaglandin- und Cytokin-vermittelten hepatischen Insulinresistenz

Bröcker-Preuß, M

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Brodzinski, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Bröring, R

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Brost, S

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Brückner, S

Charakterisierung und hepatozytäre Differenzierung von mesenchymalen Stammzellen aus dem Fettgewebe der immundefizienten Maus

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Brummelkamp, T

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Brunner, C

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Bruns, T

Pyuria in patients with cirrhosis and its impact on survival

Bucala, R

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Bücker, A

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

Buechler, C

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Buggisch, P

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Burghardt, S

The role of non-professional liver-resident APCs for inhibition of immune-mediated hepatitis in the mouse liver

Bürk, J

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Busch, D

Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

Busch, DH

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Bussemaker, H

A nuclear pore component regulates select p53 target genes

Cai, WM

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Calvisi, D

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Calvisi, DF

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

Campos, G

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Canbay, A

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Low sodium urine concentration is associated with poor survival in patients with HRS

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Canbay, AE

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Cantore, M

Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

Casey, C

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Castle, J

Identification of liver specific genes using next generation sequencing technology

Cee, A

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Ceglarek, U

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Cerny, A

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Chamulitrat, W

Protection against Cholestasis and Ischemia in vitro by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) is Associated with Upregulation of Anti-apoptotic Proteins

Das Gallensäure-Phospholipid-Konjugat Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) vermindert die LPS-vermittelte Inflammation in der Leber

Differentielle Regulation von Genen des hepatischen Lipidmetabolismus durch Ursodeoxycholyl Lysophosphatidylethanolamid in verschiedenen diätetischen Modellen der NAFLD

FATP 4 beeinflusst die Palmitat induzierte Apoptose durch Veränderung des Lipidstoffwechsels

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Chan, HLY

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Chen, JL

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Chen, X

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Chen, Y

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Christ, B

Charakterisierung und hepatozytäre Differenzierung von mesenchymalen Stammzellen aus dem Fettgewebe der immundefizienten Maus

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Churin, Y

Knochenmarktransplantation in HBV-transgenen Mäusen aggraviert die hepatische Fibrose

Hepatitis B virus surface proteins induce interferon response in the liver of HBV-transgenic mouse

Ciesek, S

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Claaß, B

Re-programming of Kupffer Cells for immune regulation in response to ConA-induced liver injury

Coenen, M

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Conchon, S

Beschleunigtes Tumorwachstum des spontanen Hepatozellulären Karzinoms (HCC) in fibrotischer/zirrhotischer Leber im Mausmodell

Cornberg, M

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

HEV-specific T-cell responses are associated with control of HEV infection

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Cornils, K

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Cubero, FJ

JNK1 is protective for the progression of NEMO-dependent hepatitis

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Cupisti, K

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

Curth, HM

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Czech, B

Atrophin 2 expression in chronic liver disease functionally affects activated hepatic stellate cells

Expression of the atypical cadherin Fat1 in hepatic fibrosis

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

D'Alessandro, LA

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Daehn, C

Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Dähn, C

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Damm, G

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Genistein shows beneficial effects on hepatic lipid metabolism in an in vitro hepatic steatosis model

Soy isoflavone Genistein affects energy metabolism in a steatotic liver model

Dandri, M

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Darnell, M

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Dauch, D

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

Dayoub, R

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

De Backer, K

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

Debey-Pascher, S

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Dechêne, A

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Decker, G

Beschleunigtes Tumorwachstum des spontanen Hepatozellulären Karzinoms (HCC) in fibrotischer/zirrhotischer Leber im Mausmodell

Delogu, S

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

De Murtas, V

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Denk, G

Die Serum-Apoptosemarker sICAM und sFAS sind bei autoimmunen Lebererkrankungen erhöht und korrelieren mit der Höhe der Serumleberwerte

De Paepe, E

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

Deray, G

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Destefanis, G

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Deterding, K

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

De Toni, EN

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Dettmer, K

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Diehl, L

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Dienes, HP

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Diepolder, H

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Dietrich, C

Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?

Dietze, O

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Di Fazio, P

Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Dollinger, M

The presence of esophageal varices (EV), but not treatment with beta-blockers, is associated with a poorer survival in patients with cirrhosis and ascites

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Dombrowski, F

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

Dong, Y

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Dooley, S

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes

Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Impact of HBV infection on TGF-β signaling in primary human hepatocytes

HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells

Dorn, C

Atrophin 2 expression in chronic liver disease functionally affects activated hepatic stellate cells

Expression of the atypical cadherin Fat1 in hepatic fibrosis

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Aging promotes hepatocellular steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis in mice

The Role of PI3K p110gamma in chronic liver injury

Enhanced TLR4 expression in steatotic hepatocytes

Xanthohumol suppresses hepatic inflammatory response to warm ischemia-reperfusion injury

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Xanthohumol improves glucose tolerance and inhibits hepatic steatosis, inflammation and fibrogenesis in a murine model of non-alcoholic steatohepatitis

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Xanthohumol inhibits hepatitis B virus replication in vitro

Dostert, K

The Role of PI3K p110gamma in chronic liver injury

Enhanced TLR4 expression in steatotic hepatocytes

Drebber, U

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Drognitz, O

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

Drvarov, O

JNK1 is protective for the progression of NEMO-dependent hepatitis

Dückers, H

Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation

Dudas, J

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Dufour, JF

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Dzieran, J

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells

Edelmann, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Ehedego, H

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

Ehlting, C

Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages

Ehnert, S

Entrapment of primary human hepatocytes in extracellular matrix gels for long term toxicity studies

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Ehrlich, A

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Eichenmüller, M

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Eiermann, T

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Eisenbach, C

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Eisenhardt, M

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Eisinger, K

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Elfimova, N

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Eloranta, J

Bile acids downregulate the human hepatic organic anion transporter 7

Endl, E

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Engelmann, G

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Eplinius, F

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Erhardt, A

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Partial loss of immunological tolerance in CCR5-deficient mice in the murine model of concanavalin A-induced liver injury

Re-programming of Kupffer Cells for immune regulation in response to ConA-induced liver injury

The role of non-professional liver-resident APCs for inhibition of immune-mediated hepatitis in the mouse liver

The role of the IL–17 axis in a mouse model of drug-induced liver injury

Ernst, D

Chronic hepatitis E in patients with CVID in Germany?

Erschfeld, S

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Ertle, JM

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

Eshraghi, P

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Esposito, I

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Evert, K

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Evert, M

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Faber, M

Phylogenetic Characterization of HEV Isolates Derived from Acute Hepatitis E Cases in Germany 2010/2011

Fabian, J

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

Impact of HBV infection on TGF-β signaling in primary human hepatocytes

HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells

Fahl, M

Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling

Falk, C

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Falk, CS

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Farkas, S

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Favreau, N

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Fazollahi, M

A nuclear pore component regulates select p53 target genes

Fehrenbacher, B

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Fehse, B

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Feng, D

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Feyerabend, S

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Fischer, K

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Fischer, P

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

Flechtenmacher, C

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Flecken, T

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

Fletcher, S

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

Flikweert, H

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Fragoulis, A

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Franke, B

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Franz, B

Chronic hepatitis E in heart transplant recipients

Frauenschuh, L

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Frei, P

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Freiberg, N

Regulation der Glukuronidierung bei Cholestase (Gallengangsligatur) und durch FXR-Agonisten im humanisierten transgenen UGT1A-Mausmodell

Geschlechtsspezifische Regulierung des Detoxifikations-Stoffwechsels: der Estrogen Receptor alpha reguliert die transkriptionelle Regulation von UDP-Glukuronosyltransferasen

Frentzen, A

Optimization of maturity levels of human hepatic cell lines in tissue culture

Frenzel, C

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Freudigmann, C

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Friedman, SL

Genetic characteristics of the human hepatic stellate cell line LX–2

Friedrich, D

Impaired FGF–19 release and hepatic FGF–19 resistance in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD)

Friess, H

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Frings, MK

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Frühwald, J

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Fülöp, B

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Furch, M

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Fürst, D

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Fytili, P

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

HEV-specific T-cell responses are associated with control of HEV infection

Gäbele, E

Novel in vitro models of alcohol-mediated hepatic injury

The Role of PI3K p110gamma in chronic liver injury

Enhanced TLR4 expression in steatotic hepatocytes

Gaestel, M

Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages

Gaiser, T

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Galle, P

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Galle, PR

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Efficacy, safety and diagnostic accuracy of ultrasound guided biopsies of focal liver lesions: a single center experience in 214 patients

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Gamstätter, T

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Gane, E

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Ganten, TM

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Ganzenmueller, T

Chronic hepatitis E in heart transplant recipients

Gao, B

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Gao, C

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

Gao, Y

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Garcia-Tsao, G

The presence of esophageal varices (EV), but not treatment with beta-blockers, is associated with a poorer survival in patients with cirrhosis and ascites

Gashi, S

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Gasparetti, G

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Gassler, N

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

JNK1 is protective for the progression of NEMO-dependent hepatitis

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Gauges, R

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Gautsch, S

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Gebhardt, R

The role of Suppressor of Fused in the regulation of Hedgehog and Wnt/ß-Catenin signaling pathway in adult liver

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Hedgehog around the clock

Charakterisierung der Smo-KO-induzierten Steatose in der Leber mittels Shotgun-Lipidomanalyse

Geidel, C

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Geier, A

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Geiger, S

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Geissinger, E

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Geissler, EK

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Gerardy-Schahn, R

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Gerbes, A

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Gerken, G

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Low sodium urine concentration is associated with poor survival in patients with HRS

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Gerlach, T

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Ghadimi, M

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Gieseler, RK

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Giugliano, S

The proapoptotic protein Bim is not differentially regulated in CD8+ T cells from resolved or chronic HCV infection

Glanemann, M

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Genistein shows beneficial effects on hepatic lipid metabolism in an in vitro hepatic steatosis model

Soy isoflavone Genistein affects energy metabolism in a steatotic liver model

Glassen, K

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

Glässner, A

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Glatzle, J

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Glaubke, C

Atypische Präsentation der Primär biliären Zirrhose bei Männern

Glebe, D

Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins

Knochenmarktransplantation in HBV-transgenen Mäusen aggraviert die hepatische Fibrose

Hepatitis B virus surface proteins induce interferon response in the liver of HBV-transgenic mouse

Godoy, P

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Goebel, R

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

Goeppert, B

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Goeser, T

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Goesseringer, R

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Göke, B

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Gonzalez-Carmona, M

Beschleunigtes Tumorwachstum des spontanen Hepatozellulären Karzinoms (HCC) in fibrotischer/zirrhotischer Leber im Mausmodell

Gordon-Walker, TT

Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling

Gotthardt, D

Protection against Cholestasis and Ischemia in vitro by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) is Associated with Upregulation of Anti-apoptotic Proteins

Gotthardt, DN

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Goumans, MJ

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Gräber, S

Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken

Grabowski, J

HEV-specific T-cell responses are associated with control of HEV infection

Granzow, M

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Granzow, R

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Grell, J

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Gronert, A

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

HEV-specific T-cell responses are associated with control of HEV infection

Grüner, N

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Grünhage, F

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases

Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie

Grünwald, D

A nuclear pore component regulates select p53 target genes

Gruss, R

Krumme Gallengänge prädisponieren zu rezidivierenden Gallengangssteinen

Gu, X

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

Gul, S

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Güldiken, N

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Günther, R

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Gupta, S

Immortalisierte humane hepatische Sternzellen migrieren schädigungsspezifisch in der Mausleber und führen zu exzessiver Leberfibrose

Gürlevik, E

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Guthke, R

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Haas, U

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Hafezi, M

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Hagmeyer, B

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Haid, S

ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS

Halank, M

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Hall, R

Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines

Evidence for a heterodimeric structure of megalin in liver macrophages

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Hammerich, L

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Handgretinger, R

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Hao, L

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Hartjen, P

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Hartl, J

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Hartmann, D

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Hashani, M

Towards unravelling the molecular mechanisms of human hepatocyte steatosis in situ

Hasselblatt, P

P2Y2 receptor function aggravates acute hepatitis by regulating neutrophil infiltration and hepatocyte survival

Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

Hatting, M

JNK1 is protective for the progression of NEMO-dependent hepatitis

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Hauns, B

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Häussinger, D

Insulin aggravates free fatty acid-induced hepatocyte cell death by activation of CD95 death receptor pathways in liver

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

The proximal TGR5 C-Terminus is required for membrane localization

Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages

Haverich, A

Chronic hepatitis E in heart transplant recipients

Haybaeck, J

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Hayden, T

Functional analysis of immunological mechanisms following mouse liver transplantation

Hebestreit, A

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Hegenbarth, S

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Heidecke, CD

Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

Heider, D

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

Heikenwälder, M

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Heilmann, J

Xanthohumol suppresses hepatic inflammatory response to warm ischemia-reperfusion injury

Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis

Hop bitter acids inhibit PD-L1 expression and tumorigenicity of hepatocellular carcinoma cells

Xanthohumol inhibits hepatitis B virus replication in vitro

Heim, A

Chronic hepatitis E in heart transplant recipients

Heim, D

Differenzierte Untersuchung direkt karzinogener Effekte von HCV-Proteinen in immortalisierten humanen Hepatozyten

Heim, I

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Heim, M

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Heinrichs, D

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Heinz, S

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Heits, N

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Helbig, M

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Held, U

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Hellerbrand, C

Atrophin 2 expression in chronic liver disease functionally affects activated hepatic stellate cells

Expression of the atypical cadherin Fat1 in hepatic fibrosis

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Novel in vitro models of alcohol-mediated hepatic injury

Aging promotes hepatocellular steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis in mice

The Role of PI3K p110gamma in chronic liver injury

Enhanced TLR4 expression in steatotic hepatocytes

GLUT 1 expression favors formation and growth of hepatic metastasis

Xanthohumol suppresses hepatic inflammatory response to warm ischemia-reperfusion injury

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Xanthohumol improves glucose tolerance and inhibits hepatic steatosis, inflammation and fibrogenesis in a murine model of non-alcoholic steatohepatitis

Hop bitter acids inhibit PD-L1 expression and tumorigenicity of hepatocellular carcinoma cells

Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Xanthohumol inhibits hepatitis B virus replication in vitro

Establishment of an in vitro model in which HBV promotes hepatocellular steatosis and lipotoxicity

Hempel, M

Charakterisierung und hepatozytäre Differenzierung von mesenchymalen Stammzellen aus dem Fettgewebe der immundefizienten Maus

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Hengstler, JG

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Henkel, J

Schlüsselrolle von PGE2 im Circulus vitiosus der Prostaglandin- und Cytokin-vermittelten hepatischen Insulinresistenz

Henrici, A

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Hentsch, B

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Herber, A

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Herbst, A

ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS

Herkel, J

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis

Herrmann, E

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Hess, G

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

Hess, J

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Heuer, M

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie

Hewitt, N

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Hey, KH

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Heymann, F

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Heyne, R

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Higuchi, A

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Hild, S

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

Himmit, M

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Hinrichsen, H

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Hinz, M

Low sodium urine concentration is associated with poor survival in patients with HRS

Hinz, U

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Ho, C

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

Höblinger, A

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie

Hochrath, K

Evidence for a heterodimeric structure of megalin in liver macrophages

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Höchst, B

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Hoepner, L

Chronische Hepatitis C Infektion: Herausforderung Alter

Hoffmann, G

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Hoffmann, S

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Hofmann, J

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Hohenester, S

Antimitochondriale Antikörper sind ungeeignet zur Diagnose der Primär Biliären Zirrhose in Mäusen

Hohmeyer, A

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

Holdenrieder, S

Die Serum-Apoptosemarker sICAM und sFAS sind bei autoimmunen Lebererkrankungen erhöht und korrelieren mit der Höhe der Serumleberwerte

Höppner, C

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Horger, M

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Horn, A

Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation

Horn-Wichmann, R

Chronic hepatitis E in patients with CVID in Germany?

Hu, W

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Hua, Q

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

Huang, J

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

Huang, T

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Huber, B

Phylogenetic Characterization of HEV Isolates Derived from Acute Hepatitis E Cases in Germany 2010/2011

HBsAg-specific humoral and cellular immune responses in children and adolescents 8–14 years after vaccination against hepatitis B

Hüneburg, R

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Hüppe, D

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Hüser, N

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Huss, S

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Ickenstein, L

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Idzko, M

P2Y2 receptor function aggravates acute hepatitis by regulating neutrophil infiltration and hepatocyte survival

Ilkavets, I

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Ingiliz, P

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Iredale, JP

Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling

Isernhagen, K

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Ittrich, H

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Jaeckel, E

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Jäger, D

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Jahn-Hofmann, K

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Jankowsky, R

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Jareis, KM

Krumme Gallengänge prädisponieren zu rezidivierenden Gallengangssteinen

Jaroszewicz, J

HEV-specific T-cell responses are associated with control of HEV infection

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Jauch, KW

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Jia, J

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Jilg, W

Phylogenetic Characterization of HEV Isolates Derived from Acute Hepatitis E Cases in Germany 2010/2011

Xanthohumol inhibits hepatitis B virus replication in vitro

HBsAg-specific humoral and cellular immune responses in children and adolescents 8–14 years after vaccination against hepatitis B

Jochum, C

Low sodium urine concentration is associated with poor survival in patients with HRS

Jochum, J

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie

Johanniemann, K

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

John, C

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

John, M

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Joka, D

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen

Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Jonas, S

The significance of appropriate controls in surgical microRNA studies of the liver

Jones, DE

Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse

Jordan, S

Chronische Hepatitis C Infektion: Herausforderung Alter

Joschko, N

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Hepatitis B Virus Infection triggers AP–1 dependent CD95Ligand expression in HepG2 cells

Jung, MC

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Jüngst, C

Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken

Bile acids downregulate the human hepatic organic anion transporter 7

ABCB4 deficiency is causative for hepatic copper accumulation in a patient with features of Wilson Disease

Kah, J

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

Kahraman, A

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Kahrmann, K

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Kaldenbach, M

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Kalff, J

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Kalthoff, S

Regulation der Glukuronidierung bei Cholestase (Gallengangsligatur) und durch FXR-Agonisten im humanisierten transgenen UGT1A-Mausmodell

Geschlechtsspezifische Regulierung des Detoxifikations-Stoffwechsels: der Estrogen Receptor alpha reguliert die transkriptionelle Regulation von UDP-Glukuronosyltransferasen

Kampschulte, M

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Kang, SM

Functional analysis of immunological mechanisms following mouse liver transplantation

Kang, TW

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

Kant, J

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Kanuri, G

Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Kappler, R

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Kashkar, H

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Katt, J

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Keitel, V

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

The proximal TGR5 C-Terminus is required for membrane localization

Keller, A

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

Keller, AD

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Kemmerling, R

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Kendziorra, E

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Kesselmeier, M

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Kessler, T

The role of the IL–17 axis in a mouse model of drug-induced liver injury

Kiesslich, T

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Kiessling, F

The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo

Kiraithe, MM

HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection

Kirchhoff, T

Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany

Kirchner, G

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Kittner, J

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Kittner, JM

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Klaas, D

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Klahn, D

Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken

Klein, I

Functional analysis of immunological mechanisms following mouse liver transplantation

Klein, K

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Bile acids downregulate the human hepatic organic anion transporter 7

Klein, S

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Kleinehr, K

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Kleuser, B

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Klingmuller, U

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Klingmüller, U

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Kloos, A

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Klumpp, K

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

Kluwe, J

Immortalisierte humane hepatische Sternzellen migrieren schädigungsspezifisch in der Mausleber und führen zu exzessiver Leberfibrose

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Knauel, M

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Knigin, D

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Knobeloch, D

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Knoblich, A

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Knoefel, WT

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

Knolle, P

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Knolle, PA

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

MHC class I transfer from stellate cells to LSEC allows for sinusoidal immunsurveillance

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Knöspel, F

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Knüppel, E

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Koc, A

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

Koch, A

Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung

GLUT 1 expression favors formation and growth of hepatic metastasis

Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation

Koch, S

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Koenig, L

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

Kofmehl, R

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Kokai, E

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Kokordelis, P

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Kolanus, W

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Koletzko, L

Establishment of an in vitro model in which HBV promotes hepatocellular steatosis and lipotoxicity

Kolligs, FT

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Köngisrainer, A

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

König, S

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Königsrainer, A

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Königsrainer, I

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Koops, A

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

Kopp, HG

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Kopsch, K

Knochenmarktransplantation in HBV-transgenen Mäusen aggraviert die hepatische Fibrose

Körner, C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Koschny, R

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Kovacs, P

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Krämer, B

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Krammer, PH

Hepatitis B Virus Infection triggers AP–1 dependent CD95Ligand expression in HepG2 cells

Krause, P

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Krawczyk, M

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases

Kreienkamp, HJ

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Kremer, S

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Krönke, M

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Kroy, DC

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Krüger, A

Genistein shows beneficial effects on hepatic lipid metabolism in an in vitro hepatic steatosis model

Soy isoflavone Genistein affects energy metabolism in a steatotic liver model

Krüger, D

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Krupp, M

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Identification of liver specific genes using next generation sequencing technology

Kubicka, S

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Kücükoglu, O

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Kudsi, H

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Kügler, M

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Kühnel, F

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Kulaksiz, H

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Krumme Gallengänge prädisponieren zu rezidivierenden Gallengangssteinen

Kulawik, A

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Kullak-Ublick, G

Bile acids downregulate the human hepatic organic anion transporter 7

Kummer, S

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Kummer, U

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Kuna, M

CAR-vermittelte Induktion des Indy-Gens in primären Rattenhepatozyten

Küper, MA

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Küper, R

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

Kurts, C

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Kutscher, S

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Kwiecinski, M

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

Lackner, K

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Lalemann, W

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Lammert, F

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines

Evidence for a heterodimeric structure of megalin in liver macrophages

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Vitamin D and depression in chronic liver disease

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken

Impaired FGF–19 release and hepatic FGF–19 resistance in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD)

Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie

Komplexe genetische Determinanten der HCC-Initiation

ABCB4 deficiency is causative for hepatic copper accumulation in a patient with features of Wilson Disease

Lampe, J

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Lang, H

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Lang, SA

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Lange, N

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Lange, S

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Langhans, B

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Langheinrich, A

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Lankisch, TO

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Latzko, P

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Lau, GK

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Lauer, UM

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Le, AQ

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Lechel, A

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Leder, A

The significance of appropriate controls in surgical microRNA studies of the liver

Lee, HW

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Lee, K

Functional analysis of immunological mechanisms following mouse liver transplantation

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Lee, S

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Lehmann, E

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Lehner, F

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Leisner, U

HBsAg-specific humoral and cellular immune responses in children and adolescents 8–14 years after vaccination against hepatitis B

Leithäuser, F

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Lembcke, C

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Leucht, AK

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Leucht, K

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Leung, NWY

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Li, J

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Li, Q

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Liebisch, G

FATP 4 beeinflusst die Palmitat induzierte Apoptose durch Veränderung des Lipidstoffwechsels

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Liebl, J

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Liedtke, C

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

JNK1 is protective for the progression of NEMO-dependent hepatitis

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Limmer, A

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Lindhorst, A

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

Linhart, M

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

Lippert, S

The significance of appropriate controls in surgical microRNA studies of the liver

Liu, Y

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Lobsien, D

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Lock, JF

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Lohmann, V

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Lohse, A

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Lohse, AW

Atypische Präsentation der Primär biliären Zirrhose bei Männern

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

Differenzierte Untersuchung direkt karzinogener Effekte von HCV-Proteinen in immortalisierten humanen Hepatozyten

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Chronische Hepatitis C Infektion: Herausforderung Alter

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Longerich, T

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Lorenzo Bermejo, J

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Loscher, C

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Loss, M

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Louis, M

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Lovas, A

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Lu, M

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Lü, S

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Lübberstedt, M

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Luda, C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Ludwig, JM

Das Gallensäure-Phospholipid-Konjugat Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) vermindert die LPS-vermittelte Inflammation in der Leber

Luedde, T

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Lui, FC

Functional analysis of immunological mechanisms following mouse liver transplantation

Lukowski, S

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

Lunova, M

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Lünse, S

Genistein shows beneficial effects on hepatic lipid metabolism in an in vitro hepatic steatosis model

Soy isoflavone Genistein affects energy metabolism in a steatotic liver model

Lupke, M

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Lütgehetmann, M

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Lüth, A

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Lüth, S

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Chronische Hepatitis C Infektion: Herausforderung Alter

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

Lutterbeck, M

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

Lutz, T

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

M´Barek, M

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

Ma, H

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

Maass, T

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

Machann, J

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Mahler, MG

Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases

Mahli, A

Novel in vitro models of alcohol-mediated hepatic injury

In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Maier, IB

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Mailk, IA

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Mainhard, M

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

Mais, A

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Maldonado, EJ

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Malek, N

Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Malek, NP

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Malik, I

PECAM–1 (CD31)-gene expression is downregulated by TNF-α or Interferon (IFN-) but upregulated by TGF–1 in peripheral blood leukocytes

Malik, IA

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Malinowski, M

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Maltman, D

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Malz, M

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Manka, P

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Manns, M

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Manns, MP

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen

Regulation der Glukuronidierung bei Cholestase (Gallengangsligatur) und durch FXR-Agonisten im humanisierten transgenen UGT1A-Mausmodell

Chronic hepatitis E in heart transplant recipients

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

HEV-specific T-cell responses are associated with control of HEV infection

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Optimization of maturity levels of human hepatic cell lines in tissue culture

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Chronic hepatitis E in patients with CVID in Germany?

Geschlechtsspezifische Regulierung des Detoxifikations-Stoffwechsels: der Estrogen Receptor alpha reguliert die transkriptionelle Regulation von UDP-Glukuronosyltransferasen

Mansuroglu, T

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Marbach, E

Hedgehog around the clock

Marhenke, S

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Marin, JJG

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Markova, A

HEV-specific T-cell responses are associated with control of HEV infection

Marquardt, J

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Marquardt, JU

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Identification of liver specific genes using next generation sequencing technology

Marquitan, G

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Marschall, HU

Impaired FGF–19 release and hepatic FGF–19 resistance in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD)

Martínez Sánchez, JJ

Entrapment of primary human hepatocytes in extracellular matrix gels for long term toxicity studies

Mathé, Z

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Mattu, S

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Matzat, V

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Matz-Soja, M

The role of Suppressor of Fused in the regulation of Hedgehog and Wnt/ß-Catenin signaling pathway in adult liver

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Hedgehog around the clock

Charakterisierung der Smo-KO-induzierten Steatose in der Leber mittels Shotgun-Lipidomanalyse

Mauss, S

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Mayer, N

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Mehrabi, A

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Meindl-Beinker, NM

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

Impact of HBV infection on TGF-β signaling in primary human hepatocytes

HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells

Meiners, J

Differenzierte Untersuchung direkt karzinogener Effekte von HCV-Proteinen in immortalisierten humanen Hepatozyten

Meinhard, M

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

Melter, M

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Menendez Menendez, K

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Mertens, PR

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Metzger, C

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Metzger, J

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Meurer, SK

More than a serum parameter: Functional relevance of soluble endoglin (solEng)

Meyer, BG

Chronic hepatitis E in patients with CVID in Germany?

Meyer, C

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Meyer, T

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Meyer-Heithuis, C

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Mihm, S

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Millonig, G

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Mischak, H

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Mollenkopf, HJ

Hepatitis B virus surface proteins induce interferon response in the liver of HBV-transgenic mouse

Möller, B

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Mönch, C

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie

Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Monin, MB

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Montalbano, R

Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Monte, MJ

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Moog, G

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Moradpour, D

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Moreno Zaldivar, M

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

Morgül, H

The significance of appropriate controls in surgical microRNA studies of the liver

Moriconi, F

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

PECAM–1 (CD31)-gene expression is downregulated by TNF-α or Interferon (IFN-) but upregulated by TGF–1 in peripheral blood leukocytes

Mössner, J

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Mueller, S

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Müllenbach, R

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Müller, A

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Müller, K

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Müller, M

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS

Hepatitis B Virus Infection triggers AP–1 dependent CD95Ligand expression in HepG2 cells

Müller, T

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Müller-Vieira, U

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Müllhaupt, B

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Mummelthei, A

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Munker, S

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Muralev, E

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Mysickova, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Nährlich, L

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Naoumov, NV

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Nashan, B

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Nattermann, J

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Naumann, U

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Naz, N

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Negm, A

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Negro, F

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Nellen, A

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Nelles, C

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Németh, J

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Neubert, W

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Neuhaus, P

The significance of appropriate controls in surgical microRNA studies of the liver

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Neumann, K

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Neumann, O

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma

Neumann-Haefelin, C

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection

Neurath, MF

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Neureiter, D

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Neuschäfer-Rube, F

CAR-vermittelte Induktion des Indy-Gens in primären Rattenhepatozyten

Nevzorova, Y

JNK1 is protective for the progression of NEMO-dependent hepatitis

Nevzorova, YA

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Newton, J

Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse

Nguyen-Tat, M

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Nierhoff, D

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Nischalke, HD

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Nitschke, K

HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection

Noetel, A

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Noll, M

Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

Nörenberg, A

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Nürnberg, P

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

Nüssler, A

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Nüssler, AK

Entrapment of primary human hepatocytes in extracellular matrix gels for long term toxicity studies

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Ocker, M

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Odenthal, M

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Oefner, P

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Oldenburg, J

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Omary, J

Die Serum-Apoptosemarker sICAM und sFAS sind bei autoimmunen Lebererkrankungen erhöht und korrelieren mit der Höhe der Serumleberwerte

Ommer, KS

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Ott, M

Optimization of maturity levels of human hepatic cell lines in tissue culture

Ottinger, S

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo

Otto, G

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Oude Elferink, R

Antimitochondriale Antikörper sind ungeeignet zur Diagnose der Primär Biliären Zirrhose in Mäusen

Ouwehand, A

A nuclear pore component regulates select p53 target genes

Pannicke, N

Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse

Pantel, K

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Pantelis, D

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Panther, E

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Panzer, U

Partial loss of immunological tolerance in CCR5-deficient mice in the murine model of concanavalin A-induced liver injury

Pascucci, M

Changes of LCN–2 gene expression in different organs in a rat model of tissue damage

Pasupuleti, S

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

Patanwala, I

Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse

Pathe-Neuschäfer-Rube, A

CAR-vermittelte Induktion des Indy-Gens in primären Rattenhepatozyten

Pathil, A

Das Gallensäure-Phospholipid-Konjugat Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) vermindert die LPS-vermittelte Inflammation in der Leber

Differentielle Regulation von Genen des hepatischen Lipidmetabolismus durch Ursodeoxycholyl Lysophosphatidylethanolamid in verschiedenen diätetischen Modellen der NAFLD

Pathil-Warth, A

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Paul, A

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

Pawella, L

Towards unravelling the molecular mechanisms of human hepatocyte steatosis in situ

Peccerella, T

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Peiseler, M

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Pelc, A

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

Pellegrino, R

AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma

Pelz, S

Charakterisierung und hepatozytäre Differenzierung von mesenchymalen Stammzellen aus dem Fettgewebe der immundefizienten Maus

Peter, H

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

Petersen, J

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Pieper-Fürst, U

Evidence for a heterodimeric structure of megalin in liver macrophages

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Pietschmann, T

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Optimization of maturity levels of human hepatic cell lines in tissue culture

ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS

Pikarsky, E

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Pinna, F

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Piratvisuth, T

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Pischke, S

Chronic hepatitis E in heart transplant recipients

HEV-specific T-cell responses are associated with control of HEV infection

Chronic hepatitis E in patients with CVID in Germany?

Plentz, R

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany

Ploschenz, C

CAR-vermittelte Induktion des Indy-Gens in primären Rattenhepatozyten

Poelstra, K

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Polywka, S

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Posselt, J

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Potthoff, A

Klinischer Langzeitverlauf von 100 Patienten mit polyzystischer Lebererkrankung – Wirksamkeit der perkutanen ultraschall-gesteuerten Sklerosierungstherapie mittels Polidocanol

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Price, DA

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

Prives, C

A nuclear pore component regulates select p53 target genes

Pronadl, M

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Proneth, A

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Protzer, U

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

Proudfoot, A

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

Pryymachuk, G

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Przyborski, S

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Pschowski, R

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Pudelski, N

Chronische Hepatitis C Infektion: Herausforderung Alter

Pufe, T

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Püschel, GP

Schlüsselrolle von PGE2 im Circulus vitiosus der Prostaglandin- und Cytokin-vermittelten hepatischen Insulinresistenz

CAR-vermittelte Induktion des Indy-Gens in primären Rattenhepatozyten

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Pusterla, T

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Quaas, A

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

Quint, K

Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Radaeva, S

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Raddatz, D

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Radlwimmer, B

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Rahman, F

Efficacy, safety and diagnostic accuracy of ultrasound guided biopsies of focal liver lesions: a single center experience in 214 patients

Ramadori, G

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

PECAM–1 (CD31)-gene expression is downregulated by TNF-α or Interferon (IFN-) but upregulated by TGF–1 in peripheral blood leukocytes

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Changes of LCN–2 gene expression in different organs in a rat model of tissue damage

Ramadori, P

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Raschzok, NJ

The significance of appropriate controls in surgical microRNA studies of the liver

Rasenack, J

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Raskopf, E

Toxische Leberschädigung führt im Mausmodell zu einem vermehrten Einwandern von Endothelzellen und endothelialen Vorläuferzellen

Die Gabe von Nexavar beeinflusst in hypoxischen Cholangiokarzinomzellen das Zellüberleben

Rath, T

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Rau, M

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Raue, A

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Rauen, U

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Raupach, R

Chronic hepatitis E in heart transplant recipients

Chronic hepatitis E in patients with CVID in Germany?

Ray, S

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Real, CI

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Regel, I

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Reich, M

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

Reichert, B

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Reif, R

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Reinehr, R

Insulin aggravates free fatty acid-induced hepatocyte cell death by activation of CD95 death receptor pathways in liver

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

Reiser, J

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Ren, H

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Resheq, Y

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

Reuken, PA

Pyuria in patients with cirrhosis and its impact on survival

Ribback, S

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

Ricken, A

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Riedl, P

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Riemenschneider, M

Vitamin D and depression in chronic liver disease

Riethausen, K

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Riethdorf, S

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Rizzani, A

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Rockstroh, J

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Röder, C

Chronische Hepatitis C Infektion: Herausforderung Alter

Roderfeld, M

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Knochenmarktransplantation in HBV-transgenen Mäusen aggraviert die hepatische Fibrose

Hepatitis B virus surface proteins induce interferon response in the liver of HBV-transgenic mouse

Roeb, E

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Knochenmarktransplantation in HBV-transgenen Mäusen aggraviert die hepatische Fibrose

Hepatitis B virus surface proteins induce interferon response in the liver of HBV-transgenic mouse

Rogler, G

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Rohde, S

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen

Röhnert, P

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Ronkina, N

Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages

Roos, K

ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS

Rosendahl, J

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Rudolph, KL

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Rüdrich, U

Optimization of maturity levels of human hepatic cell lines in tissue culture

Ruffert, C

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Rupp, C

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Russmann, S

Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients

Rust, C

Die Serum-Apoptosemarker sICAM und sFAS sind bei autoimmunen Lebererkrankungen erhöht und korrelieren mit der Höhe der Serumleberwerte

Rybicki, A

Die Gabe von Nexavar beeinflusst in hypoxischen Cholangiokarzinomzellen das Zellüberleben

Ryschich, E

Influence of IL–1β and IL–1 receptor antagonist on T-cell adhesion to hepatic endothelial cells: a potential implication for leukocyte recruitment in HCC

Sahin, H

The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo

G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9

Sales, S

Charakterisierung der Smo-KO-induzierten Steatose in der Leber mittels Shotgun-Lipidomanalyse

Sallmon, H

The significance of appropriate controls in surgical microRNA studies of the liver

Salnikova, O

Influence of IL–1β and IL–1 receptor antagonist on T-cell adhesion to hepatic endothelial cells: a potential implication for leukocyte recruitment in HCC

Sandig, C

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Saner, F

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Sarrazin, C

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Sass, G

Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Sauer, IM

The significance of appropriate controls in surgical microRNA studies of the liver

Sauer, P

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Sauerbruch, T

Beschleunigtes Tumorwachstum des spontanen Hepatozellulären Karzinoms (HCC) in fibrotischer/zirrhotischer Leber im Mausmodell

Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Toxische Leberschädigung führt im Mausmodell zu einem vermehrten Einwandern von Endothelzellen und endothelialen Vorläuferzellen

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Die Gabe von Nexavar beeinflusst in hypoxischen Cholangiokarzinomzellen das Zellüberleben

Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Saugspier, M

Expression of the atypical cadherin Fat1 in hepatic fibrosis

Aging promotes hepatocellular steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis in mice

The Role of PI3K p110gamma in chronic liver injury

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Hop bitter acids inhibit PD-L1 expression and tumorigenicity of hepatocellular carcinoma cells

In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Schadmand-Fischer, S

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Schäffler, A

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Schaller, M

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Schanze, N

Schlüsselrolle von PGE2 im Circulus vitiosus der Prostaglandin- und Cytokin-vermittelten hepatischen Insulinresistenz

Scharfenberg, A

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Schattenberg, JM

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Schelcher, C

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Scheller, K

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Schemmer, P

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Schenk, M

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Scherbaum, N

The proapoptotic protein Bim is not differentially regulated in CD8+ T cells from resolved or chronic HCV infection

Scherer, MN

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Scheulen, ME

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Scheurich, C

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Schiene-Fischer, C

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Schierwagen, R

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Schievenbusch, S

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Schiffelholz, W

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Schildberg, F

MHC class I transfer from stellate cells to LSEC allows for sinusoidal immunsurveillance

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Schildberg, FA

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Schildgen, J

Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes

Schindler, F

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes

Schirmacher, P

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma

A nuclear pore component regulates select p53 target genes

Towards unravelling the molecular mechanisms of human hepatocyte steatosis in situ

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Schirmbeck, R

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Schlaak, JF

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro

In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes

Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Schlaphoff, V

HEV-specific T-cell responses are associated with control of HEV infection

Schlattjan, M

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Bariatric surgery ameliorates NAFLD in morbidly obese patients

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Schleicher, S

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Schlitt, HJ

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Schlueter, H

Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes

Schmid, S

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Schmidt, N

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

Schmidt, RE

Chronic hepatitis E in patients with CVID in Germany?

Schmidt, W

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Schmidt-Heck, W

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Schmitt, E

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Schmitt, J

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Schmitz, G

FATP 4 beeinflusst die Palmitat induzierte Apoptose durch Veränderung des Lipidstoffwechsels

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Schmitz, P

The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Schmitz, V

Toxische Leberschädigung führt im Mausmodell zu einem vermehrten Einwandern von Endothelzellen und endothelialen Vorläuferzellen

Die Gabe von Nexavar beeinflusst in hypoxischen Cholangiokarzinomzellen das Zellüberleben

Schneider, B

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Schneider, S

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Schnitzbauer, AA

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Schober, A

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Scholten, D

G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9

Schölzel, K

MHC class I transfer from stellate cells to LSEC allows for sinusoidal immunsurveillance

Schott, E

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Schrader, J

Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling

Schramm, C

Atypische Präsentation der Primär biliären Zirrhose bei Männern

Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis

Schraplau, A

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Schreckenbach, T

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie

Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Schreiter, T

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Schuchmann, M

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Schughart, K

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Schultheiß, M

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Schultz, F

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Schultze, JL

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Schulz, R

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Schulze, A

Optimization of maturity levels of human hepatic cell lines in tissue culture

Schulze, K

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Schulze-Bergkamen, H

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Schulze zur Wiesch, J

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Chronische Hepatitis C Infektion: Herausforderung Alter

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Schumacher, F

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Schütte, J

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Schwab, M

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Schwinge, D

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Schyschka, L

Entrapment of primary human hepatocytes in extracellular matrix gels for long term toxicity studies

Sebode, M

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis

Seehofer, D

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Seeßle, J

FATP 4 beeinflusst die Palmitat induzierte Apoptose durch Veränderung des Lipidstoffwechsels

Seidler, S

Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung

Seif, A

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Seigel, B

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection

Seitz, HK

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Sellge, G

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Sellinger, M

Protection against Cholestasis and Ischemia in vitro by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) is Associated with Upregulation of Anti-apoptotic Proteins

Setchell, K

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Seufferlein, T

The presence of esophageal varices (EV), but not treatment with beta-blockers, is associated with a poorer survival in patients with cirrhosis and ascites

Seyfarth, HJ

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Shen, H

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Shevchenko, A

Charakterisierung der Smo-KO-induzierten Steatose in der Leber mittels Shotgun-Lipidomanalyse

Sial, GZK

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Sibbing, B

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Sicinski, P

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Sieber, S

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Siegmund, B

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

Siegmund, SV

Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Singer, MV

Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis

Singer, R

A nuclear pore component regulates select p53 target genes

Singer, SR

A nuclear pore component regulates select p53 target genes

Sinn, B

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Sirma, H

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Siveke, J

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Skibbe, K

The proapoptotic protein Bim is not differentially regulated in CD8+ T cells from resolved or chronic HCV infection

Smirnow, I

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Soboletzki, M

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

Sobottka, I

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Söhne, J

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Sommerfeld, A

Insulin aggravates free fatty acid-induced hepatocyte cell death by activation of CD95 death receptor pathways in liver

TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

Sowa, JP

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

miR–101 im komplexen Zusammenspiel von Steatose und Steatohepatitis bei Nicht-Alkoholischen Fettlebererkrankungen

Spangenberg, HC

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

speicher, T

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Spengler, U

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Gestörte Funktion von CD56high CXCR3(+) NK Zellen als möglicher neuer Mechanismus der HCV-assoziierten Leberfibrose

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Spomer, L

The proximal TGR5 C-Terminus is required for membrane localization

Sprinzl, MF

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

Spruss, A

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Stabenow, D

Viral infection sensitizes hepatocytes towards TNF-induced apoptosis

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

MHC class I transfer from stellate cells to LSEC allows for sinusoidal immunsurveillance

Staib, F

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Stallmach, A

Pyuria in patients with cirrhosis and its impact on survival

Staratschek-Jox, A

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Stark, K

Phylogenetic Characterization of HEV Isolates Derived from Acute Hepatitis E Cases in Germany 2010/2011

Staufer, K

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Stein, I

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Steinebrunner, N

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Steinmann, E

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Stelzle, M

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Stenzinger, A

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Stevens, A

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Stiefel, J

Knochenmarktransplantation in HBV-transgenen Mäusen aggraviert die hepatische Fibrose

Stiefel, P

Chronic hepatitis E in heart transplant recipients

Stieger, B

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Stiehl, A

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Stock, MK

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

Stock, P

Charakterisierung und hepatozytäre Differenzierung von mesenchymalen Stammzellen aus dem Fettgewebe der immundefizienten Maus

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Stockmann, M

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Stoehr, A

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Stokes, CS

Vitamin D and depression in chronic liver disease

Strack, I

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

Strand, S

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Strassburg, CP

Regulation der Glukuronidierung bei Cholestase (Gallengangsligatur) und durch FXR-Agonisten im humanisierten transgenen UGT1A-Mausmodell

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Geschlechtsspezifische Regulierung des Detoxifikations-Stoffwechsels: der Estrogen Receptor alpha reguliert die transkriptionelle Regulation von UDP-Glukuronosyltransferasen

Straub, B

Towards unravelling the molecular mechanisms of human hepatocyte steatosis in situ

Streetz, K

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Streich, R

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Stremmel, W

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

Protection against Cholestasis and Ischemia in vitro by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) is Associated with Upregulation of Anti-apoptotic Proteins

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury

Das Gallensäure-Phospholipid-Konjugat Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) vermindert die LPS-vermittelte Inflammation in der Leber

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Differentielle Regulation von Genen des hepatischen Lipidmetabolismus durch Ursodeoxycholyl Lysophosphatidylethanolamid in verschiedenen diätetischen Modellen der NAFLD

FATP 4 beeinflusst die Palmitat induzierte Apoptose durch Veränderung des Lipidstoffwechsels

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS

Hepatitis B Virus Infection triggers AP–1 dependent CD95Ligand expression in HepG2 cells

Strnad, P

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Krumme Gallengänge prädisponieren zu rezidivierenden Gallengangssteinen

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Strüver, N

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Stubenrauch, F

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Suermann, T

Persistent HCV-infection and liver damage change vitamin-D-metabolism

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Sultan, S

Changes of LCN–2 gene expression in different organs in a rat model of tissue damage

Sunami, Y

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Suneetha, PV

Chronic hepatitis E in heart transplant recipients

HEV-specific T-cell responses are associated with control of HEV infection

Supplieth, M

Chronische Hepatitis C Infektion: Herausforderung Alter

Sydow, K

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Sykora, J

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Tacke, F

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung

Evidence for a heterodimeric structure of megalin in liver macrophages

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation

Talas, G

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Tautenhahn, M

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Taylor, J

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

ten Dijke, P

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Tennert, C

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Teuber, G

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Teufel, A

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Identification of liver specific genes using next generation sequencing technology

Teufel, U

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Thasler, WE

Novel in vitro models of alcohol-mediated hepatic injury

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Hop bitter acids inhibit PD-L1 expression and tumorigenicity of hepatocellular carcinoma cells

In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Thelen, A

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Thiel, S

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Thiele, A

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Thimme, R

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection

Thomaschewski, M

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Thomssen, A

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Thonig, A

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Thorgeirsson, SS

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Tiegs, G

Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

Partial loss of immunological tolerance in CCR5-deficient mice in the murine model of concanavalin A-induced liver injury

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Re-programming of Kupffer Cells for immune regulation in response to ConA-induced liver injury

The role of non-professional liver-resident APCs for inhibition of immune-mediated hepatitis in the mouse liver

The role of the IL–17 axis in a mouse model of drug-induced liver injury

Timm, J

Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro

The proapoptotic protein Bim is not differentially regulated in CD8+ T cells from resolved or chronic HCV infection

Timmer, J

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Timo, W

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Tóth, I

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Trautwein, C

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo

G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation

JNK1 is protective for the progression of NEMO-dependent hepatitis

c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Trebicka, J

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Treckmann, J

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Tribica, J

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Triebel, J

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Trierweiler, C

Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

Trippler, M

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Trylesinski, A

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Tschaharganeh, DF

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Tschuschner, A

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Tuncay, S

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Urban, S

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

Impact of HBV infection on TGF-β signaling in primary human hepatocytes

Urbanik, T

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Usachov, V

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Valletta, D

Atrophin 2 expression in chronic liver disease functionally affects activated hepatic stellate cells

Expression of the atypical cadherin Fat1 in hepatic fibrosis

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Van Beuge, M

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

van Bömmel, F

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

van de Leur, E

More than a serum parameter: Functional relevance of soluble endoglin (solEng)

Van de Leur, E

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

van Endert, P

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Vangeneugden, T

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

van Heeswijk, R

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir – Effect of Different Types of Food

van Lunzen, J

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Vaulont, S

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Venturelli, S

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Vermehren, J

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Viedt-Suelmann, C

Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?

Vogel, A

Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Vogt, A

Beschleunigtes Tumorwachstum des spontanen Hepatozellulären Karzinoms (HCC) in fibrotischer/zirrhotischer Leber im Mausmodell

Toxische Leberschädigung führt im Mausmodell zu einem vermehrten Einwandern von Endothelzellen und endothelialen Vorläuferzellen

Vollmar, A

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Volynets, V

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Volz, T

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

von Figura, G

Krumme Gallengänge prädisponieren zu rezidivierenden Gallengangssteinen

Von Hahn, T

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

von Renteln, D

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

von Schweinitz, D

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Wachtlin, D

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Wacker, E

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

Wagnerberger, S

Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Wahl, K

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen

Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Waizmann, M

Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting

Walczak, H

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Waldherr, R

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

Walsh, K

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Walter, R

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Wang, B

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Wang, C

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

Wanninger, J

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Warth, A

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Differentielle Regulation von Genen des hepatischen Lipidmetabolismus durch Ursodeoxycholyl Lysophosphatidylethanolamid in verschiedenen diätetischen Modellen der NAFLD

Wasmuth, HE

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo

G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Weber, K

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Weber, S

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Weber, SN

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Komplexe genetische Determinanten der HCC-Initiation

Wedemeyer, H

Chronic hepatitis E in heart transplant recipients

Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

HEV-specific T-cell responses are associated with control of HEV infection

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Chronic hepatitis E in patients with CVID in Germany?

Wedemeyer, J

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Wege, H

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

Differenzierte Untersuchung direkt karzinogener Effekte von HCV-Proteinen in immortalisierten humanen Hepatozyten

Wegscheid, C

Partial loss of immunological tolerance in CCR5-deficient mice in the murine model of concanavalin A-induced liver injury

Weichert, W

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Weiland, T

Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Weiler-Normann, C

Atypische Präsentation der Primär biliären Zirrhose bei Männern

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis

Weimer, J

Genetic characteristics of the human hepatic stellate cell line LX–2

Weinmann, A

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

Weiskirchen, R

Genetic characteristics of the human hepatic stellate cell line LX–2

More than a serum parameter: Functional relevance of soluble endoglin (solEng)

Evidence for a heterodimeric structure of megalin in liver macrophages

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

Weiss, KH

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Weiss, TS

Atrophin 2 expression in chronic liver disease functionally affects activated hepatic stellate cells

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Novel in vitro models of alcohol-mediated hepatic injury

Enhanced TLR4 expression in steatotic hepatocytes

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

Increased expression of the glucose transporter GLUT1 in liver fibrosis

Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Weiß, M

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Weiß, T

Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

Weisskopf, M

Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients

Wendel, A

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Weng, H

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

Weng, HL

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Wenske, G

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Wenzel, JJ

Phylogenetic Characterization of HEV Isolates Derived from Acute Hepatitis E Cases in Germany 2010/2011

HBsAg-specific humoral and cellular immune responses in children and adolescents 8–14 years after vaccination against hepatitis B

Werner, N

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

Werner, T

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

Werner, W

The significance of appropriate controls in surgical microRNA studies of the liver

Westphal, H

Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

Wichert, M

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

Widera, A

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

Wiechert, L

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Wiegand, J

Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Wiegand, S

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Wiegard, C

Atypische Präsentation der Primär biliären Zirrhose bei Männern

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis

Wiercinska, E

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Wietzke-Braun, P

IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

Wilke, HJ

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie

Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Williams, RW

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Willim, K

Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

Wimmer, AE

More than a serum parameter: Functional relevance of soluble endoglin (solEng)

Wimmer, R

Die Serum-Apoptosemarker sICAM und sFAS sind bei autoimmunen Lebererkrankungen erhöht und korrelieren mit der Höhe der Serumleberwerte

Winkel, N

The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

Winkelmann, C

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Winkler, A

Regulation der Glukuronidierung bei Cholestase (Gallengangsligatur) und durch FXR-Agonisten im humanisierten transgenen UGT1A-Mausmodell

Geschlechtsspezifische Regulierung des Detoxifikations-Stoffwechsels: der Estrogen Receptor alpha reguliert die transkriptionelle Regulation von UDP-Glukuronosyltransferasen

Wirth, JW

Immortalisierte humane hepatische Sternzellen migrieren schädigungsspezifisch in der Mausleber und führen zu exzessiver Leberfibrose

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Wirth, T

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Witte, T

Chronic hepatitis E in patients with CVID in Germany?

Wittenburg, H

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Witthöft, T

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)

Woerns, MA

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Wojtalla, A

Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis

Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Wolfgramm, S

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Wolkersdörfer, G

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Woller, N

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

Wolter, F

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt

HCV-vermittelte Blockierung der IL–2 Sekretion von CD4(+) T-Zellen hemmt die anti-fibrotische Aktivität von NK-Zellen

Wönne, EC

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Wörns, M

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Wörns, MA

Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

Wortmann, F

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Wree, A

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Low sodium urine concentration is associated with poor survival in patients with HRS

Bariatric surgery ameliorates NAFLD in morbidly obese patients

Wruck, C

Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung

Wursthorn, K

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Wüstenberg, A

Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Xu, L

Genetic characteristics of the human hepatic stellate cell line LX–2

Xu, W

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Yan, X

Entrapment of primary human hepatocytes in extracellular matrix gels for long term toxicity studies

Zacher, B

Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Zakhari, S

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Zapf, A

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Zeilinger, K

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Zellmer, S

Charakterisierung der Smo-KO-induzierten Steatose in der Leber mittels Shotgun-Lipidomanalyse

Zeman, F

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Zender, L

In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

Zeuzem, S

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Zhang, W

Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Zhao, G

JNK1 is protective for the progression of NEMO-dependent hepatitis

Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis

Ziegler, S

Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro

Zimmer, A

Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis

Zimmer, V

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie

ABCB4 deficiency is causative for hepatic copper accumulation in a patient with features of Wilson Disease

Zimmermann, HW

Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung

Zimmermann, M

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Zipprich, A

The presence of esophageal varices (EV), but not treatment with beta-blockers, is associated with a poorer survival in patients with cirrhosis and ascites

Zorger, N

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Zoufaly, A

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie

Zucknick, M

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Zwank, C

Der NKp46-Rezeptor ist an der Regulation der anti-fibrotischen Aktivität von NK Zellen beteiligt